Androgen receptors in prostate cancer

R. White DeV., C. A. Olsson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

One possible measurement of the endocrine sensitivity of a target tumor is the presence of an appropriate steroid receptor protein within the tumor tissue. This relationship has been well established in various animal tumor models as well as in women with breast cancer. If the same relationship between hormone receptor content and endocrine responsiveness could be established in human prostate cancer, knowledge of androgen receptor content in prostate cancer may serve to predict responsiveness to orchiectomy, antiandrogen treatment, or estrogen therapy. Since 25 per cent of patients with prostate cancer are anticipated to have endocrine-resistant tumors, these individuals would be spared needless surgery or the complications of unnecessary endocrine intervention. In this article we review the progress that has been achieved in predicting endocrine responsiveness of metastatic prostate cancer, paying particular attention to recent developments in androgen receptor (AR) measurement.

Original languageEnglish
Pages (from-to)24-26
Number of pages3
JournalUrology
Volume17
Issue numberSuppl. 4
StatePublished - 1981
Externally publishedYes

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