Androgen receptor functions in male and female physiology

Takahiro Matsumoto; Hiroko Shiina; Hirotaka Kawano; Takashi Sato; Shigeaki Kato

doi:10.1016/j.jsbmb.2008.03.023

Androgen receptor functions in male and female physiology

Takahiro Matsumoto
, Hiroko Shiina
, Hirotaka Kawano
, Takashi Sato
, Shigeaki Kato

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Abstract

The biological actions of androgens are mediated by transcriptional control of target genes through binding to the androgen receptor (AR). The AR belongs to the nuclear receptor superfamily and acts as a ligand-inducible transcriptional factor. Androgens/AR system is thought to be central to male physiology and behaviors to the development of clinical pathology. The physiological importance of AR function currently recognized in female reproduction also has been verified in mouse genetic model. Here we review functions of AR in male and female physiology as revealed by mice lacking AR.

Original language	English
Pages (from-to)	236-241
Number of pages	6
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	109
Issue number	3-5
DOIs	https://doi.org/10.1016/j.jsbmb.2008.03.023
State	Published - Apr 2008
Externally published	Yes

Keywords

Androgen receptor (AR)
Androgen receptor knockout mouse (ARKO)
Female physiology
Folliculogenesis

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10.1016/j.jsbmb.2008.03.023

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title = "Androgen receptor functions in male and female physiology",

abstract = "The biological actions of androgens are mediated by transcriptional control of target genes through binding to the androgen receptor (AR). The AR belongs to the nuclear receptor superfamily and acts as a ligand-inducible transcriptional factor. Androgens/AR system is thought to be central to male physiology and behaviors to the development of clinical pathology. The physiological importance of AR function currently recognized in female reproduction also has been verified in mouse genetic model. Here we review functions of AR in male and female physiology as revealed by mice lacking AR.",

keywords = "Androgen receptor (AR), Androgen receptor knockout mouse (ARKO), Female physiology, Folliculogenesis",

author = "Takahiro Matsumoto and Hiroko Shiina and Hirotaka Kawano and Takashi Sato and Shigeaki Kato",

note = "Funding Information: This work was supported in part by a grant-in-aid for priority areas from the Ministry of Education, Science, Sports and Culture of Japan (S.K.).",

year = "2008",

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doi = "10.1016/j.jsbmb.2008.03.023",

language = "English",

volume = "109",

pages = "236--241",

journal = "Journal of Steroid Biochemistry and Molecular Biology",

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T1 - Androgen receptor functions in male and female physiology

AU - Matsumoto, Takahiro

AU - Shiina, Hiroko

AU - Kawano, Hirotaka

AU - Sato, Takashi

AU - Kato, Shigeaki

N1 - Funding Information: This work was supported in part by a grant-in-aid for priority areas from the Ministry of Education, Science, Sports and Culture of Japan (S.K.).

PY - 2008/4

Y1 - 2008/4

N2 - The biological actions of androgens are mediated by transcriptional control of target genes through binding to the androgen receptor (AR). The AR belongs to the nuclear receptor superfamily and acts as a ligand-inducible transcriptional factor. Androgens/AR system is thought to be central to male physiology and behaviors to the development of clinical pathology. The physiological importance of AR function currently recognized in female reproduction also has been verified in mouse genetic model. Here we review functions of AR in male and female physiology as revealed by mice lacking AR.

AB - The biological actions of androgens are mediated by transcriptional control of target genes through binding to the androgen receptor (AR). The AR belongs to the nuclear receptor superfamily and acts as a ligand-inducible transcriptional factor. Androgens/AR system is thought to be central to male physiology and behaviors to the development of clinical pathology. The physiological importance of AR function currently recognized in female reproduction also has been verified in mouse genetic model. Here we review functions of AR in male and female physiology as revealed by mice lacking AR.

KW - Androgen receptor (AR)

KW - Androgen receptor knockout mouse (ARKO)

KW - Female physiology

KW - Folliculogenesis

UR - https://www.scopus.com/pages/publications/43849099238

U2 - 10.1016/j.jsbmb.2008.03.023

DO - 10.1016/j.jsbmb.2008.03.023

M3 - Review article

C2 - 18434134

AN - SCOPUS:43849099238

SN - 0960-0760

VL - 109

SP - 236

EP - 241

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

IS - 3-5

ER -

Androgen receptor functions in male and female physiology

Abstract

Keywords

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