Anaplerotic effect of propionyl carnitine in rat heart mitochondria

V. Tassani; F. Cattapan; L. Magnanimi; A. Peschechera

doi:10.1006/bbrc.1994.1321

Anaplerotic effect of propionyl carnitine in rat heart mitochondria

V. Tassani, F. Cattapan, L. Magnanimi, A. Peschechera

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48 Scopus citations

Abstract

Carnitine and propionyl carnitine both increase production of ¹⁴CO₂ from [1-¹⁴C]pyruvate but only the latter, in a process inhibited by malonate, increases oxygen uptake and ¹⁴CO₂ evolution fiom [2-¹⁴C]pyruvate. Carnitine increases the rate of formation of acetyl carnitine from pyruvate to a greater extent than propionyl carnitine. These effects of carnitine and propionyl carnitine are not detectable in mitochondria (e.g., rat liver) deficient in carnitine acetyl transferase activity.

Original language	English
Pages (from-to)	949-953
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	199
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1994.1321
State	Published - 15 Mar 1994
Externally published	Yes

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title = "Anaplerotic effect of propionyl carnitine in rat heart mitochondria",

abstract = "Carnitine and propionyl carnitine both increase production of 14CO2 from [1-14C]pyruvate but only the latter, in a process inhibited by malonate, increases oxygen uptake and 14CO2 evolution fiom [2-14C]pyruvate. Carnitine increases the rate of formation of acetyl carnitine from pyruvate to a greater extent than propionyl carnitine. These effects of carnitine and propionyl carnitine are not detectable in mitochondria (e.g., rat liver) deficient in carnitine acetyl transferase activity.",

author = "V. Tassani and F. Cattapan and L. Magnanimi and A. Peschechera",

year = "1994",

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AU - Cattapan, F.

AU - Magnanimi, L.

AU - Peschechera, A.

PY - 1994/3/15

Y1 - 1994/3/15

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AB - Carnitine and propionyl carnitine both increase production of 14CO2 from [1-14C]pyruvate but only the latter, in a process inhibited by malonate, increases oxygen uptake and 14CO2 evolution fiom [2-14C]pyruvate. Carnitine increases the rate of formation of acetyl carnitine from pyruvate to a greater extent than propionyl carnitine. These effects of carnitine and propionyl carnitine are not detectable in mitochondria (e.g., rat liver) deficient in carnitine acetyl transferase activity.

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JO - Biochemical and Biophysical Research Communications

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ER -

Anaplerotic effect of propionyl carnitine in rat heart mitochondria

Abstract

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