Analysis of the p53-hMDM2-p21 (WAF1/CIP1) cell cycle regulation pathway in malignant fibrous histiocytomas

Ulrich Brinck; Thilo Schlott; Carlos Cordon-Cardo; Jerzy Stachura; Martin Walz; Gösta Fischer; Monika Korabiowska

Analysis of the p53-hMDM2-p21 (WAF1/CIP1) cell cycle regulation pathway in malignant fibrous histiocytomas

Ulrich Brinck, Thilo Schlott, Carlos Cordon-Cardo, Jerzy Stachura, Martin Walz, Gösta Fischer, Monika Korabiowska

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This study was undertaken to analyze patterns of expression of critical cell cycle regulators (CCR) involved in the p53 pathway in malignant fibrous histiocytomas (MFH). Protein expression was assessed using immunohistochemistry analyzing p53, hMDM2 and p21 (WAF1/CIP1) phenotypes. p53- and hMDM2-positive phenotypes were found to be associated with low p21 levels (p0.01). Positive hMDM2 phenotype did not correlate with any hMDM2 mutations, which in our tumor collective were not found. High-grade MFH differed from MFH grade I and II concerning higher p53 and lower p21 levels, while hMDM2 expression was independent of grade. Inclusion of categorized values into a Cox regression study proved the independent prognostic relevance of p53, hMDM2 and p21 phenotypes.

Original language	English
Pages (from-to)	419-426
Number of pages	8
Journal	Cancer Genomics and Proteomics
Volume	1
Issue number	5-6
State	Published - 2004
Externally published	Yes

Keywords

Cell cycle regulators
MDM2
MFH
P21
P53

Cite this

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title = "Analysis of the p53-hMDM2-p21 (WAF1/CIP1) cell cycle regulation pathway in malignant fibrous histiocytomas",

abstract = "This study was undertaken to analyze patterns of expression of critical cell cycle regulators (CCR) involved in the p53 pathway in malignant fibrous histiocytomas (MFH). Protein expression was assessed using immunohistochemistry analyzing p53, hMDM2 and p21 (WAF1/CIP1) phenotypes. p53- and hMDM2-positive phenotypes were found to be associated with low p21 levels (p0.01). Positive hMDM2 phenotype did not correlate with any hMDM2 mutations, which in our tumor collective were not found. High-grade MFH differed from MFH grade I and II concerning higher p53 and lower p21 levels, while hMDM2 expression was independent of grade. Inclusion of categorized values into a Cox regression study proved the independent prognostic relevance of p53, hMDM2 and p21 phenotypes.",

keywords = "Cell cycle regulators, MDM2, MFH, P21, P53",

author = "Ulrich Brinck and Thilo Schlott and Carlos Cordon-Cardo and Jerzy Stachura and Martin Walz and G{\"o}sta Fischer and Monika Korabiowska",

year = "2004",

language = "English",

volume = "1",

pages = "419--426",

journal = "Cancer Genomics and Proteomics",

issn = "1109-6535",

publisher = "International Institute of Anticancer Research",

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T1 - Analysis of the p53-hMDM2-p21 (WAF1/CIP1) cell cycle regulation pathway in malignant fibrous histiocytomas

AU - Brinck, Ulrich

AU - Schlott, Thilo

AU - Cordon-Cardo, Carlos

AU - Stachura, Jerzy

AU - Walz, Martin

AU - Fischer, Gösta

AU - Korabiowska, Monika

PY - 2004

Y1 - 2004

N2 - This study was undertaken to analyze patterns of expression of critical cell cycle regulators (CCR) involved in the p53 pathway in malignant fibrous histiocytomas (MFH). Protein expression was assessed using immunohistochemistry analyzing p53, hMDM2 and p21 (WAF1/CIP1) phenotypes. p53- and hMDM2-positive phenotypes were found to be associated with low p21 levels (p0.01). Positive hMDM2 phenotype did not correlate with any hMDM2 mutations, which in our tumor collective were not found. High-grade MFH differed from MFH grade I and II concerning higher p53 and lower p21 levels, while hMDM2 expression was independent of grade. Inclusion of categorized values into a Cox regression study proved the independent prognostic relevance of p53, hMDM2 and p21 phenotypes.

AB - This study was undertaken to analyze patterns of expression of critical cell cycle regulators (CCR) involved in the p53 pathway in malignant fibrous histiocytomas (MFH). Protein expression was assessed using immunohistochemistry analyzing p53, hMDM2 and p21 (WAF1/CIP1) phenotypes. p53- and hMDM2-positive phenotypes were found to be associated with low p21 levels (p0.01). Positive hMDM2 phenotype did not correlate with any hMDM2 mutations, which in our tumor collective were not found. High-grade MFH differed from MFH grade I and II concerning higher p53 and lower p21 levels, while hMDM2 expression was independent of grade. Inclusion of categorized values into a Cox regression study proved the independent prognostic relevance of p53, hMDM2 and p21 phenotypes.

KW - Cell cycle regulators

KW - MDM2

KW - MFH

KW - P21

KW - P53

UR - http://www.scopus.com/inward/record.url?scp=33750742894&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33750742894

SN - 1109-6535

VL - 1

SP - 419

EP - 426

JO - Cancer Genomics and Proteomics

JF - Cancer Genomics and Proteomics

IS - 5-6

ER -

Analysis of the p53-hMDM2-p21 (WAF1/CIP1) cell cycle regulation pathway in malignant fibrous histiocytomas

Abstract

Keywords

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