Analysis of the insertion/deletion polymorphism of the human angiotensin converting enzyme (ACE) gene in patients with renal cancer

B. A. Usmani; M. Janeczko; R. Shen; M. Mazumdar; C. N. Papandreou; D. M. Nanus

doi:10.1054/bjoc.1999.0962

Analysis of the insertion/deletion polymorphism of the human angiotensin converting enzyme (ACE) gene in patients with renal cancer

B. A. Usmani
, M. Janeczko
, R. Shen
, M. Mazumdar
, C. N. Papandreou
, D. M. Nanus

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The angiotensin I-converting enzyme (ACE) contains an insertion/deletion (I/D) polymorphism, with the DD genotype associated with benign renal diseases. The distribution frequencies of the D and I alleles, and the DD, DI and II genotypes were determined in DNA extracted from kidney tissues of 58 renal cancer patients. The observed frequencies in patients who develop renal cancer was not significantly different than the normal population. (C) 2000 Cancer Research Campaign.

Original language	English
Pages (from-to)	550-552
Number of pages	3
Journal	British Journal of Cancer
Volume	82
Issue number	3
DOIs	https://doi.org/10.1054/bjoc.1999.0962
State	Published - 2000
Externally published	Yes

Keywords

ACE
Kidney
Polymorphism
Renal cancer

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10.1054/bjoc.1999.0962

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title = "Analysis of the insertion/deletion polymorphism of the human angiotensin converting enzyme (ACE) gene in patients with renal cancer",

abstract = "The angiotensin I-converting enzyme (ACE) contains an insertion/deletion (I/D) polymorphism, with the DD genotype associated with benign renal diseases. The distribution frequencies of the D and I alleles, and the DD, DI and II genotypes were determined in DNA extracted from kidney tissues of 58 renal cancer patients. The observed frequencies in patients who develop renal cancer was not significantly different than the normal population. (C) 2000 Cancer Research Campaign.",

keywords = "ACE, Kidney, Polymorphism, Renal cancer",

author = "Usmani, \{B. A.\} and M. Janeczko and R. Shen and M. Mazumdar and Papandreou, \{C. N.\} and Nanus, \{D. M.\}",

note = "Funding Information: The authors thank Ms Jennifer Wilkes for expert technical assistance, Dr Victor Reuter for review of pathology specimens and Dr Pierre Corvol for useful discussions. This study was supported in part by NIH Grant CA 57475.",

year = "2000",

doi = "10.1054/bjoc.1999.0962",

language = "English",

volume = "82",

pages = "550--552",

journal = "British Journal of Cancer",

issn = "0007-0920",

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number = "3",

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TY - JOUR

T1 - Analysis of the insertion/deletion polymorphism of the human angiotensin converting enzyme (ACE) gene in patients with renal cancer

AU - Usmani, B. A.

AU - Janeczko, M.

AU - Shen, R.

AU - Mazumdar, M.

AU - Papandreou, C. N.

AU - Nanus, D. M.

N1 - Funding Information: The authors thank Ms Jennifer Wilkes for expert technical assistance, Dr Victor Reuter for review of pathology specimens and Dr Pierre Corvol for useful discussions. This study was supported in part by NIH Grant CA 57475.

PY - 2000

Y1 - 2000

N2 - The angiotensin I-converting enzyme (ACE) contains an insertion/deletion (I/D) polymorphism, with the DD genotype associated with benign renal diseases. The distribution frequencies of the D and I alleles, and the DD, DI and II genotypes were determined in DNA extracted from kidney tissues of 58 renal cancer patients. The observed frequencies in patients who develop renal cancer was not significantly different than the normal population. (C) 2000 Cancer Research Campaign.

AB - The angiotensin I-converting enzyme (ACE) contains an insertion/deletion (I/D) polymorphism, with the DD genotype associated with benign renal diseases. The distribution frequencies of the D and I alleles, and the DD, DI and II genotypes were determined in DNA extracted from kidney tissues of 58 renal cancer patients. The observed frequencies in patients who develop renal cancer was not significantly different than the normal population. (C) 2000 Cancer Research Campaign.

KW - ACE

KW - Kidney

KW - Polymorphism

KW - Renal cancer

UR - https://www.scopus.com/pages/publications/0033967372

U2 - 10.1054/bjoc.1999.0962

DO - 10.1054/bjoc.1999.0962

M3 - Article

C2 - 10682664

AN - SCOPUS:0033967372

SN - 0007-0920

VL - 82

SP - 550

EP - 552

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 3

ER -

Analysis of the insertion/deletion polymorphism of the human angiotensin converting enzyme (ACE) gene in patients with renal cancer

Abstract

Keywords

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