@article{0dbbffe8fa6e423fb76f7d2e4bcd11dd,
title = "Analysis of Postdeployment Serum Samples Identifies Potential Biomarkers of Exposure to Burn Pits and Other Environmental Hazards",
abstract = "Objective:The potential health risks of deployment to sites with open burn pits remain poorly understood, in part, because personal exposure monitoring was not performed. Here, we investigated whether postdeployment serum samples contain biomarkers associated with exposure to burn pits.Methods:A total of 237 biomarkers were measured in 800 serum samples from deployed and never-deployed subjects. We used a regression model and a supervised vector machine to identify serum biomarkers with significant associations with exposures and deployment.Results:We identified 101 serum biomarkers associated with polycyclic aromatic hydrocarbons, dioxins or furans, and 54 biomarkers associated with deployment. Twenty-six of these biomarkers were shared in common by the exposure and deployment groups.Conclusions:We identify a potential signature of exposure to open burn pits, and provide a framework for using postexposure sera to identify exposures when contemporaneous monitoring was inadequate.",
keywords = "burn pits, deployment, dioxins, exposure assessment, microRNA",
author = "Thatcher, {Thomas H.} and Woeller, {Collynn F.} and Juilee Thakar and Atif Khan and Hopke, {Philip K.} and Smith, {Matthew Ryan} and Karan Uppal and Walker, {Douglas I.} and Go, {Young Mi} and Jones, {Dean P.} and Krahl, {Pamela L.} and Mallon, {Timothy M.} and Sime, {Patricia J.} and Phipps, {Richard P.} and Utell, {Mark J.}",
note = "Funding Information: Funding: This work was supported in part by The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. grant no. HT9404-13-1-0030, the National Institute of Environmental Health Sciences grant no. P30ES01247, and NIH training grant no. T32HL066988. The opinions expressed are those of the authors and do not necessarily reflect the official positions of the Uniformed Services University, the U.S. Department of Defense, Clarkson University or the University of Rochester. Publisher Copyright: {\textcopyright} 2019 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited.",
year = "2019",
month = dec,
day = "1",
doi = "10.1097/JOM.0000000000001715",
language = "English",
volume = "61",
pages = "S45--S54",
journal = "Journal of Occupational and Environmental Medicine",
issn = "1076-2752",
publisher = "Lippincott Williams and Wilkins Ltd.",
}