Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients

Alexander Varzari; Kathrin Bruch; Igor V. Deyneko; Andrew Chan; Joerg T. Epplen; Sabine Hoffjan

doi:10.1016/j.jneuroim.2014.09.015

Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients

Alexander Varzari, Kathrin Bruch, Igor V. Deyneko, Andrew Chan, Joerg T. Epplen, Sabine Hoffjan

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Variation in genes encoding retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs) has been implicated in the pathogenesis of autoimmune disorders. We investigated if polymorphisms in the IFIH1, RIG-. I, LGP2 and VISA genes influence the risk for multiple sclerosis (MS) in a German case-control cohort comprising 716 patients and 706 controls. Evaluation of 18 single nucleotide polymorphisms (SNPs) in the four genes did not reveal significant single-SNP associations with MS risk, but two VISA polymorphisms were modestly associated with age of onset. Further, we provide initial evidence for combinatorial effects of polymorphic variants in the RIG-. I, LGP2 and IFIH1 genes on MS risk.

Original language	English
Pages (from-to)	140-144
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	277
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2014.09.015
State	Published - 15 Dec 2014
Externally published	Yes

Keywords

Association
Combinatorial effect
Multiple sclerosis
RIG-I-like receptors
RLRs

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10.1016/j.jneuroim.2014.09.015

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title = "Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients",

abstract = "Variation in genes encoding retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs) has been implicated in the pathogenesis of autoimmune disorders. We investigated if polymorphisms in the IFIH1, RIG-. I, LGP2 and VISA genes influence the risk for multiple sclerosis (MS) in a German case-control cohort comprising 716 patients and 706 controls. Evaluation of 18 single nucleotide polymorphisms (SNPs) in the four genes did not reveal significant single-SNP associations with MS risk, but two VISA polymorphisms were modestly associated with age of onset. Further, we provide initial evidence for combinatorial effects of polymorphic variants in the RIG-. I, LGP2 and IFIH1 genes on MS risk.",

keywords = "Association, Combinatorial effect, Multiple sclerosis, RIG-I-like receptors, RLRs",

author = "Alexander Varzari and Kathrin Bruch and Deyneko, {Igor V.} and Andrew Chan and Epplen, {Joerg T.} and Sabine Hoffjan",

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T1 - Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients

AU - Varzari, Alexander

AU - Bruch, Kathrin

AU - Deyneko, Igor V.

AU - Chan, Andrew

AU - Epplen, Joerg T.

AU - Hoffjan, Sabine

PY - 2014/12/15

Y1 - 2014/12/15

N2 - Variation in genes encoding retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs) has been implicated in the pathogenesis of autoimmune disorders. We investigated if polymorphisms in the IFIH1, RIG-. I, LGP2 and VISA genes influence the risk for multiple sclerosis (MS) in a German case-control cohort comprising 716 patients and 706 controls. Evaluation of 18 single nucleotide polymorphisms (SNPs) in the four genes did not reveal significant single-SNP associations with MS risk, but two VISA polymorphisms were modestly associated with age of onset. Further, we provide initial evidence for combinatorial effects of polymorphic variants in the RIG-. I, LGP2 and IFIH1 genes on MS risk.

AB - Variation in genes encoding retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs) has been implicated in the pathogenesis of autoimmune disorders. We investigated if polymorphisms in the IFIH1, RIG-. I, LGP2 and VISA genes influence the risk for multiple sclerosis (MS) in a German case-control cohort comprising 716 patients and 706 controls. Evaluation of 18 single nucleotide polymorphisms (SNPs) in the four genes did not reveal significant single-SNP associations with MS risk, but two VISA polymorphisms were modestly associated with age of onset. Further, we provide initial evidence for combinatorial effects of polymorphic variants in the RIG-. I, LGP2 and IFIH1 genes on MS risk.

KW - Association

KW - Combinatorial effect

KW - Multiple sclerosis

KW - RIG-I-like receptors

KW - RLRs

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Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients

Abstract

Keywords

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