Analysis of gene polymorphisms in the regulatory region of MCP-1, RANTES, and CCR5 in liver transplant recipients

Bernd Schröppel, Michael Fischereder, Marvin Lin, Brad Marder, Tom Schiano, Bernhard K. Krämer, Barbara Murphy

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Chemokines and their receptors play a major role in the inflammatory and immune responses that mediate allograft outcome. The production of some chemokines varies among individuals and these variations may be determined by genetic polymorphisms, most commonly within the regulatory region of the gene. We investigated whether the functional polymorphisms of the chemokines RANTES, MCP-1 and chemokine receptor CCR5 are associated with the incidence of acute rejection and long-term liver graft survival. Two hundred nine liver transplant recipients were genotyped using polymerase chain reaction sequence-specific primers for the following polymorphisms: RANTES-28, MCP-1 -2518, and CCR5-59029. There was no association with any of the three genotypes and the incidence of acute rejection episodes. In addition, no association of RANTES-28, MCP-1 -2518, or CCR5 -59029 variants with long-term liver graft survival was found. In conclusion, variants of RANTES-28, MCP-1 -2518, and CCR5-59029 neither influenced the incidence of acute rejection nor affected long-term allograft survival upon liver transplantation in the context of this analysis.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalJournal of Clinical Immunology
Volume22
Issue number6
DOIs
StatePublished - Nov 2002

Keywords

  • CCR5
  • Graft survival
  • Liver transplantation
  • MCP-1
  • RANTES
  • Rejection

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