Analysis of DNA mismatch repair gene expression and mutations in thyroid tumours

Ilka Ruschenburg, Beate Vollheim, Jerzy Stachura, Carlos Cordon-Cardo, Monika Korabiowska

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Alterations of DNA mismatch repair genes, primarily demonstrated in hereditary nonpolyposis colorectal carcinomas, were reported to be of relevance for the progression of several sporadic tumours. In this study, the expression and mutations of MLH1, MSH2, PMS1 and PMS2 in a panel of thyroid tumours, including nodular hyperplasia, follicular adenomas and carcinomas, were investigated. The expressions of MLH1, MSH2 and PMS1 were generally higher in malignant tumours than in benign lesions (p<0.01). This observation can find potential diagnostic application in the differentiation of follicular adenomas from follicullar carcinomas of the thyroid. No point mutations in the DNA mismatch repair genes MSH2 (exon 12, 13) and MLH1 (exon 15, 16) were found.

Original languageEnglish
Pages (from-to)2107-2112
Number of pages6
JournalAnticancer Research
Volume26
Issue number3 A
StatePublished - May 2006
Externally publishedYes

Keywords

  • DNA mismatch repair
  • MLH1
  • MSH2
  • PMS1
  • PMS2
  • Thyroid cancer

Fingerprint

Dive into the research topics of 'Analysis of DNA mismatch repair gene expression and mutations in thyroid tumours'. Together they form a unique fingerprint.

Cite this