Analysis of clustered and interval censored data from a community-based study in asthma

Scarlett L. Bellamy, Yi Li, Louise M. Ryan, Stuart Lipsitz, Marina J. Canner, Rosalind Wright

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Many authors in recent years have proposed extensions of familiar survival analysis methodologies to apply in dependent data settings, for example, when data are clustered or subject to repeated measures. However, these extensions have been considered largely in the context of right censored data. In this paper, we discuss a parametric frailty model for the analysis of clustered and interval censored failure time data. Details are presented for the specific case where the underlying time to event data follow a Weibull distribution. Maximum likelihood estimates will be obtained using commercially available software and the empirical efficiency of these estimators will be explored via a simulation study. We also discuss a score test to make inferences about the magnitude and significance of over-dispersion in clustered data settings. These methods will be illustrated using data from the East Boston Asthma Study.

Original languageEnglish
Pages (from-to)3607-3621
Number of pages15
JournalStatistics in Medicine
Volume23
Issue number23
DOIs
StatePublished - 15 Dec 2004
Externally publishedYes

Keywords

  • Censoring
  • Clustering
  • Frailty
  • Over-dispersion
  • Survival analysis

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