Abstract
Mobilization regimens for CD34+ cells have generally been judged successful based on the number of cells collected without evaluating mobilization separately from collection. Using retrospective data for patients who collected CD34+ cells on Total Therapy protocols 3a/3b (VTD-PACE) and Total Therapy 4/5 using a novel regimen that added low dose melphalan to VTD-PACE (MVTD-PACE), we analyzed mobilization and collection variables separately. A significant difference favoring MVDT-PACE was found in mean CD34+ cells/μL on day 2 of collection and in mean ratio of CD34+ cells/μL on day 2 to day 1. However, because apheresis variables and growth factor dose during collection were manipulated to optimize individual collections, the two regimens were not significantly different when the mean total CD34+ cells ×106/kg collected was compared. Thus, when evaluating a emotherapy regimen or new growth factor for mobilization, it is important to realize that total CD34+ cells collected is dependent on both mobilization and collection variables.
Original language | English |
---|---|
Pages (from-to) | 251-255 |
Number of pages | 5 |
Journal | Journal of Clinical Apheresis |
Volume | 29 |
Issue number | 5 |
DOIs | |
State | Published - 1 Oct 2014 |
Externally published | Yes |
Keywords
- Apheresis
- CD34+
- Melphalan
- Mobilization
- Myeloma