Analysis of an interaction threshold in a mixture of drugs and/or chemicals

Adam K. Hamm, W. Hans Carter, Chris Gennings

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Increasingly, humans are exposed to drug/chemical mixtures. These exposures can result from therapeutic interventions or environmental sources. Of interest is the interaction that may occur among the components of these mixtures. Since interaction can be dose-dependent, it is important to determine exposure levels to either exploit the benefits of the interaction in a therapeutic application or to avoid the effect of the interaction in the case of an environmental risk assessment. We propose generalized linear models that permit the estimation of interaction threshold boundaries. The methods developed are applied to the combination of ethanol and chloral hydrate.

Original languageEnglish
Pages (from-to)2493-2507
Number of pages15
JournalStatistics in Medicine
Volume24
Issue number16
DOIs
StatePublished - 30 Aug 2005
Externally publishedYes

Keywords

  • Chemical mixtures
  • Dose-dependent interaction
  • Drug combinations
  • Segmented regions
  • Synergism
  • Threshold model

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