Analgesia Following Sulfapyridine Administration in Morphine-Pretreated Mice: A Morphine “Reservoir”?

Chryssanthos P. Chryssanthou

doi:10.3181/00379727-144-37679

Analgesia Following Sulfapyridine Administration in Morphine-Pretreated Mice: A Morphine “Reservoir”?

Chryssanthos P. Chryssanthou

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Sulfapyridine potentiates the analgesic effect of morphine. It also produces analgesia when administered to morphinepretreated mice long after the analgesic effect of morphine has worn off. Morphine possibly binds to blood and/or tissue components, most likely in the brain, forming pharmacologically inactive complexes, and sulfapyridine prevents and/or reverses the binding, thus freeing active morphine.

Original language	English
Pages (from-to)	770-773
Number of pages	4
Journal	Experimental Biology and Medicine
Volume	144
Issue number	3
DOIs	https://doi.org/10.3181/00379727-144-37679
State	Published - Dec 1973
Externally published	Yes

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title = "Analgesia Following Sulfapyridine Administration in Morphine-Pretreated Mice: A Morphine {\textquotedblleft}Reservoir{\textquotedblright}?",

abstract = "Sulfapyridine potentiates the analgesic effect of morphine. It also produces analgesia when administered to morphinepretreated mice long after the analgesic effect of morphine has worn off. Morphine possibly binds to blood and/or tissue components, most likely in the brain, forming pharmacologically inactive complexes, and sulfapyridine prevents and/or reverses the binding, thus freeing active morphine.",

author = "Chryssanthou, \{Chryssanthos P.\}",

note = "Funding Information: Supported by U.S. Public Health Service, NIH Grant FRO5492 and the Lenore Weinstein Fund. 2 ",

year = "1973",

month = dec,

doi = "10.3181/00379727-144-37679",

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volume = "144",

pages = "770--773",

journal = "Experimental Biology and Medicine",

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T1 - Analgesia Following Sulfapyridine Administration in Morphine-Pretreated Mice

T2 - A Morphine “Reservoir”?

AU - Chryssanthou, Chryssanthos P.

N1 - Funding Information: Supported by U.S. Public Health Service, NIH Grant FRO5492 and the Lenore Weinstein Fund. 2

PY - 1973/12

Y1 - 1973/12

N2 - Sulfapyridine potentiates the analgesic effect of morphine. It also produces analgesia when administered to morphinepretreated mice long after the analgesic effect of morphine has worn off. Morphine possibly binds to blood and/or tissue components, most likely in the brain, forming pharmacologically inactive complexes, and sulfapyridine prevents and/or reverses the binding, thus freeing active morphine.

AB - Sulfapyridine potentiates the analgesic effect of morphine. It also produces analgesia when administered to morphinepretreated mice long after the analgesic effect of morphine has worn off. Morphine possibly binds to blood and/or tissue components, most likely in the brain, forming pharmacologically inactive complexes, and sulfapyridine prevents and/or reverses the binding, thus freeing active morphine.

UR - https://www.scopus.com/pages/publications/0015865481

U2 - 10.3181/00379727-144-37679

DO - 10.3181/00379727-144-37679

M3 - Article

C2 - 4765957

AN - SCOPUS:0015865481

SN - 0037-9727

VL - 144

SP - 770

EP - 773

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

IS - 3

ER -

Analgesia Following Sulfapyridine Administration in Morphine-Pretreated Mice: A Morphine “Reservoir”?

Abstract

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