TY - JOUR
T1 - Analgesia Following Sulfapyridine Administration in Morphine-Pretreated Mice
T2 - A Morphine “Reservoir”?
AU - Chryssanthou, Chryssanthos P.
N1 - Funding Information:
Supported by U.S. Public Health Service, NIH Grant FRO5492 and the Lenore Weinstein Fund. 2
PY - 1973/12
Y1 - 1973/12
N2 - Sulfapyridine potentiates the analgesic effect of morphine. It also produces analgesia when administered to morphinepretreated mice long after the analgesic effect of morphine has worn off. Morphine possibly binds to blood and/or tissue components, most likely in the brain, forming pharmacologically inactive complexes, and sulfapyridine prevents and/or reverses the binding, thus freeing active morphine.
AB - Sulfapyridine potentiates the analgesic effect of morphine. It also produces analgesia when administered to morphinepretreated mice long after the analgesic effect of morphine has worn off. Morphine possibly binds to blood and/or tissue components, most likely in the brain, forming pharmacologically inactive complexes, and sulfapyridine prevents and/or reverses the binding, thus freeing active morphine.
UR - http://www.scopus.com/inward/record.url?scp=0015865481&partnerID=8YFLogxK
U2 - 10.3181/00379727-144-37679
DO - 10.3181/00379727-144-37679
M3 - Article
C2 - 4765957
AN - SCOPUS:0015865481
SN - 0037-9727
VL - 144
SP - 770
EP - 773
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 3
ER -