Analgesia following intraventricular administration of 2-deoxy-D-gluocse

Richard J. Bodnar, Kevin P. Merrigan, Margaret M. Wallace

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The glucose analogue, 2-deoxy-D-glucose (2-DG) elicits hyperphagic and analgesic responses in rats. The former response appears to be mediated by central processes since overeating is elicited following intraventricular administration of 2-DG at low (3.5 and 5.0 mg/kg) doses. The present study examined whether flinch-jump thresholds would increase 30, 90 and 180 min following intraventricular injections of 2-DG at low (3.5, 5.0 and 10.0 mg/kg) doses and compared these effects with systemically-applied 2-DG doses of 350 and 500 mg/kg. Intraventricular 2-DG administration increased jump thresholds for up to 180 min across all test doses. Flinch thresholds were also increased, but in a manner dissociated from jump thresholds. Animals with cannulae located near, but not in the lateral ventricle, displayed delayed analgesic effects. The magnitude of intraventricular 2-DG analgesia was not as potent as the 100-fold higher systemic injections. It appears that central mechanisms mediated intraventricular 2-DG analgesia at the low dose range since higher, systemic 2-DG doses have previously failed to increase flinch-jump thresholds.

Original languageEnglish
Pages (from-to)579-581
Number of pages3
JournalPharmacology Biochemistry and Behavior
Volume14
Issue number4
DOIs
StatePublished - Apr 1981
Externally publishedYes

Keywords

  • 2-Deoxy-D-glucose
  • Analgesia
  • Pain
  • Rats

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