@article{0eac88108d4f4049b74ce13df5d55bc2,
title = "An NIMH Workshop on Non-Affective Psychosis in Midlife and Beyond: Research Agenda on Phenomenology, Clinical Trajectories, Underlying Mechanisms, and Intervention Targets",
abstract = "We present a review of the state of the research in the phenomenology, clinical trajectories, biological mechanisms, aging biomarkers, and treatments for middle-aged and older people with schizophrenia (PwS) discussed at the NIMH sponsored workshop “Non-affective Psychosis in Midlife and Beyond.” The growing population of PwS has specific clinical needs that require tailored and mechanistically derived interventions. Differentiating between the effects of aging and disease progression is a key challenge of studying older PwS. This review of the workshop highlights the recent findings in this understudied clinical population and the critical gaps in knowledge and consensus for research priorities. This review showcases the major challenges and opportunities for research to advance clinical care for this growing and understudied population.",
keywords = "Schizophrenia, aging, biomarkers, cognition, treatment",
author = "{Members of the NIMH Workshop on Non-Affective Psychosis in Midlife and Beyond} and Lee, {Ellen E.} and Adamowicz, {David H.} and Sophia Frangou",
note = "Funding Information: This study was supported, in part, by the National Institute of Mental Health K23MH119375-01 (PI: Ellen E. Lee), R25MH101072 (PI: Neal R. Swerdlow), A Havens Established Investigator Grant from The Brain & Behavior Research Foundation (PI: EEL), the Desert-Pacific Mental Illness Research Education and Clinical Center at the VA San Diego Healthcare System (EEL), as well as the Stein Institute for Research on Aging at the University of California San Diego. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the federal government or the National Institutes of Health (NIH). Funding Information: This study was supported, in part, by the National Institute of Mental Health K23MH119375-01 (PI: Ellen E. Lee), R25MH101072 (PI: Neal R. Swerdlow), A Havens Established Investigator Grant from The Brain & Behavior Research Foundation (PI: EEL), the Desert-Pacific Mental Illness Research Education and Clinical Center at the VA San Diego Healthcare System (EEL), as well as the Stein Institute for Research on Aging at the University of California San Diego. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the federal government or the National Institutes of Health (NIH). Publisher Copyright: {\textcopyright} 2023 American Association for Geriatric Psychiatry",
year = "2023",
month = may,
doi = "10.1016/j.jagp.2023.01.019",
language = "English",
volume = "31",
pages = "353--365",
journal = "American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Elsevier Inc.",
number = "5",
}