TY - JOUR
T1 - An investigation of the possible interaction between the use of Vitamin C and highly active antiretroviral therapy (HAART) adherence and effectiveness in treated HIV+ women
AU - Merenstein, Daniel
AU - Wang, Cuiwei
AU - Gandhi, Monica
AU - Robison, Esther
AU - Levine, Alexandra M.
AU - Schwartz, Rebecca M.
AU - Weber, Kathleen M.
AU - Liu, Chenglong
PY - 2012/8
Y1 - 2012/8
N2 - Objectives: Our goal in this study was to examine how Vitamin C interacts with antiretroviral therapy in individuals with HIV. We specifically evaluated how Vitamin C impacts highly active antiretroviral therapy (HAART) adherence and HAART effectiveness as adjudicated by HIV viral loads and CD4 cell counts. Women served as their own controls, comparing periods of Vitamin C usage with periods of non-usage. Design: An intra-individual, cross-sectional comparative study 'nested' in the WIHS observational cohort study. Subjects: Women in the Women's Interagency HIV Study (WIHS). Outcome measures: Adherence, CD4 count and viral load. Results: Our study population was drawn from 2813 HIV+ participants who contributed 44,588 visits in WIHS from October, 1994 to April, 2009. Among them, there were 1122 Vitamin C users with 4954 total visits where use was reported. In the multivariate model adjusting for age, education, race, income, drug use, Vitamin C use order and depression score, there was a 44% increase in the odds of ≥95% HAART adherence among participants during their period of Vitamin C use compared to when they were not using Vitamin C (OR. =. 1.44; 95% CI. =. 1.1-1.9; . P-value. =. 0.0179). There was an association with Vitamin C usage and CD4 counts on viral loads. Conclusion: Vitamin C usage appears to be associated with improved adherence. Future Vitamin C studies should target specific HAART drugs, and prospective clinical outcomes.
AB - Objectives: Our goal in this study was to examine how Vitamin C interacts with antiretroviral therapy in individuals with HIV. We specifically evaluated how Vitamin C impacts highly active antiretroviral therapy (HAART) adherence and HAART effectiveness as adjudicated by HIV viral loads and CD4 cell counts. Women served as their own controls, comparing periods of Vitamin C usage with periods of non-usage. Design: An intra-individual, cross-sectional comparative study 'nested' in the WIHS observational cohort study. Subjects: Women in the Women's Interagency HIV Study (WIHS). Outcome measures: Adherence, CD4 count and viral load. Results: Our study population was drawn from 2813 HIV+ participants who contributed 44,588 visits in WIHS from October, 1994 to April, 2009. Among them, there were 1122 Vitamin C users with 4954 total visits where use was reported. In the multivariate model adjusting for age, education, race, income, drug use, Vitamin C use order and depression score, there was a 44% increase in the odds of ≥95% HAART adherence among participants during their period of Vitamin C use compared to when they were not using Vitamin C (OR. =. 1.44; 95% CI. =. 1.1-1.9; . P-value. =. 0.0179). There was an association with Vitamin C usage and CD4 counts on viral loads. Conclusion: Vitamin C usage appears to be associated with improved adherence. Future Vitamin C studies should target specific HAART drugs, and prospective clinical outcomes.
KW - Complementary and alternative medicines (CAM)
KW - Highly active antiretroviral therapy (HAART)
KW - Vitamin C
KW - Women's health
UR - https://www.scopus.com/pages/publications/84860835186
U2 - 10.1016/j.ctim.2012.03.001
DO - 10.1016/j.ctim.2012.03.001
M3 - Article
C2 - 22579434
AN - SCOPUS:84860835186
SN - 0965-2299
VL - 20
SP - 222
EP - 227
JO - Complementary Therapies in Medicine
JF - Complementary Therapies in Medicine
IS - 4
ER -