@article{5d0dc9fa2b6640e9b9a44104528ad19b,
title = "An interaction between dietary tryptophan and stress in exacerbating gastric disease",
abstract = "Rats fed a tryptophan deficient diet composed of corn developed significantly more gastric erosive disease when subjected to prolonged immobilization than similarly stressed rats fed a tryptophan enriched diet. No gastric disease developed in control groups which were not immobilized. No significant correlations were found between treatment groups and levels of indoleamines in brain and gut. However, serum tryptophan was significantly lowered only in the group of stressed rats fed a tryptophan deficient diet. This report raises the possibility that people eating preponderantly a corn-based diet, deficient in tryptophan, may be at increased risk of having stress ulcer disease of the gut.",
keywords = "5-HIAA, Brain, Gut, Nutrition, Rats, Serotonin, Stress, Tryptophan",
author = "Natelson, {Benjamin H.} and Laura Janocko and Jacoby, {Jacob H.}",
note = "Funding Information: Twenty-eight female Sprague-Dawley rats (Taconic Farms, Germantown, NY), weighing 200-225 g, were used in these experiments. The rats were acclimated for 1 week to our laboratory conditions (singly housed in mesh bottom cages with ad lib Purina rat chow and water; lights on 12 hr a day). After this time, external food holders were removed and feeding jars (provided graciously by Dr. I. Faust) were attached inside the cages. These jars were 7.5 cm high and had a screw-on top with a 4.5 cm opening punched in its center. The jars were packed 2/3 full with one of two diets: a 15% by weight corn/corn oil diet composed of white Masa ~This research was supported by VA medical research funds and a Career Development Award to BHN. ~Address reprint requests to Benjamin H. Natelson, MD, Department of Neurosciences, New Jersey Medical School, 88 Ross Street, East Orange, NJ 07018. aThe authors acknowledge the statistical advice of Jean Chou and the secretarial aid of L. Fox.",
year = "1981",
month = feb,
doi = "10.1016/0031-9384(81)90011-1",
language = "English",
volume = "26",
pages = "197--200",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "2",
}