An inside job—CHIP infiltrates and promotes cancer

Brian Y. Soong; Nader Yatim; Miriam Merad

doi:10.1016/j.immuni.2025.05.014

An inside job—CHIP infiltrates and promotes cancer

Brian Y. Soong
, Nader Yatim
, Miriam Merad

Marc and Jennifer Lipschultz Precision Immunology Institute

Research output: Contribution to journal › Comment/debate

Abstract

Somatic mutations in hematopoietic stem cells can lead to clonal hematopoiesis of indeterminate potential (CHIP), a frequent condition associated with many age-related diseases including solid cancer. In the New England Journal of Medicine, Pich et al. report that tumor-infiltrating CHIP correlates with worsened cancer prognosis and clinical outcomes, providing evidence for the impact of mutated immune cells on disease progression.

Original language	English
Pages (from-to)	1375-1377
Number of pages	3
Journal	Immunity
Volume	58
Issue number	6
DOIs	https://doi.org/10.1016/j.immuni.2025.05.014
State	Published - 10 Jun 2025

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10.1016/j.immuni.2025.05.014

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title = "An inside job—CHIP infiltrates and promotes cancer",

abstract = "Somatic mutations in hematopoietic stem cells can lead to clonal hematopoiesis of indeterminate potential (CHIP), a frequent condition associated with many age-related diseases including solid cancer. In the New England Journal of Medicine, Pich et al. report that tumor-infiltrating CHIP correlates with worsened cancer prognosis and clinical outcomes, providing evidence for the impact of mutated immune cells on disease progression.",

author = "Soong, \{Brian Y.\} and Nader Yatim and Miriam Merad",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

month = jun,

day = "10",

doi = "10.1016/j.immuni.2025.05.014",

language = "English",

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journal = "Immunity",

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TY - JOUR

T1 - An inside job—CHIP infiltrates and promotes cancer

AU - Soong, Brian Y.

AU - Yatim, Nader

AU - Merad, Miriam

PY - 2025/6/10

Y1 - 2025/6/10

N2 - Somatic mutations in hematopoietic stem cells can lead to clonal hematopoiesis of indeterminate potential (CHIP), a frequent condition associated with many age-related diseases including solid cancer. In the New England Journal of Medicine, Pich et al. report that tumor-infiltrating CHIP correlates with worsened cancer prognosis and clinical outcomes, providing evidence for the impact of mutated immune cells on disease progression.

AB - Somatic mutations in hematopoietic stem cells can lead to clonal hematopoiesis of indeterminate potential (CHIP), a frequent condition associated with many age-related diseases including solid cancer. In the New England Journal of Medicine, Pich et al. report that tumor-infiltrating CHIP correlates with worsened cancer prognosis and clinical outcomes, providing evidence for the impact of mutated immune cells on disease progression.

UR - https://www.scopus.com/pages/publications/105007325839

U2 - 10.1016/j.immuni.2025.05.014

DO - 10.1016/j.immuni.2025.05.014

M3 - Comment/debate

AN - SCOPUS:105007325839

SN - 1074-7613

VL - 58

SP - 1375

EP - 1377

JO - Immunity

JF - Immunity

IS - 6

ER -

An inside job—CHIP infiltrates and promotes cancer

Abstract

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