An innovative biologic system for photon-powered myocardium in the ischemic heart

Jeffrey E. Cohen; Andrew B. Goldstone; Michael J. Paulsen; Yasuhiro Shudo; Amanda N. Steele; Bryan B. Edwards; Jay B. Patel; John W. MacArthur; Michael S. Hopkins; Casey E. Burnett; Kevin J. Jaatinen; Akshara D. Thakore; Justin M. Farry; Vi N. Truong; Alexandra T. Bourdillon; Lyndsay M. Stapleton; Anahita Eskandari; Alexander S. Fairman; William Hiesinger; Tatiana V. Esipova; William L. Patrick; Keven Ji; Judith A. Shizuru; Y. Joseph Woo

doi:10.1126/sciadv.1603078

An innovative biologic system for photon-powered myocardium in the ischemic heart

Jeffrey E. Cohen, Andrew B. Goldstone, Michael J. Paulsen, Yasuhiro Shudo, Amanda N. Steele, Bryan B. Edwards, Jay B. Patel, John W. MacArthur, Michael S. Hopkins, Casey E. Burnett, Kevin J. Jaatinen, Akshara D. Thakore, Justin M. Farry, Vi N. Truong, Alexandra T. Bourdillon, Lyndsay M. Stapleton, Anahita Eskandari, Alexander S. Fairman, William Hiesinger, Tatiana V. EsipovaWilliam L. Patrick, Keven Ji, Judith A. Shizuru, Y. Joseph Woo

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium Synechococcus elongatus. By using light rather than blood flow as a source of energy, photosynthetic therapy increases tissue oxygenation, maintains myocardial metabolism, and yields durable improvements in cardiac function during and after induction of ischemia. By circumventing blood flow entirely to provide tissue with oxygen and nutrients, this system has the potential to create a paradigm shift in the way ischemic heart disease is treated.

Original language	English
Article number	e1603078
Journal	Science advances
Volume	3
Issue number	6
DOIs	https://doi.org/10.1126/sciadv.1603078
State	Published - Jun 2017
Externally published	Yes

Access to Document

10.1126/sciadv.1603078

Cite this

Cohen, J. E., Goldstone, A. B., Paulsen, M. J., Shudo, Y., Steele, A. N., Edwards, B. B., Patel, J. B., MacArthur, J. W., Hopkins, M. S., Burnett, C. E., Jaatinen, K. J., Thakore, A. D., Farry, J. M., Truong, V. N., Bourdillon, A. T., Stapleton, L. M., Eskandari, A., Fairman, A. S., Hiesinger, W., ... Woo, Y. J. (2017). An innovative biologic system for photon-powered myocardium in the ischemic heart. Science advances, 3(6), Article e1603078. https://doi.org/10.1126/sciadv.1603078

@article{65b70514d21a4aec8c9a14076bfc156c,

title = "An innovative biologic system for photon-powered myocardium in the ischemic heart",

abstract = "Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium Synechococcus elongatus. By using light rather than blood flow as a source of energy, photosynthetic therapy increases tissue oxygenation, maintains myocardial metabolism, and yields durable improvements in cardiac function during and after induction of ischemia. By circumventing blood flow entirely to provide tissue with oxygen and nutrients, this system has the potential to create a paradigm shift in the way ischemic heart disease is treated.",

author = "Cohen, \{Jeffrey E.\} and Goldstone, \{Andrew B.\} and Paulsen, \{Michael J.\} and Yasuhiro Shudo and Steele, \{Amanda N.\} and Edwards, \{Bryan B.\} and Patel, \{Jay B.\} and MacArthur, \{John W.\} and Hopkins, \{Michael S.\} and Burnett, \{Casey E.\} and Jaatinen, \{Kevin J.\} and Thakore, \{Akshara D.\} and Farry, \{Justin M.\} and Truong, \{Vi N.\} and Bourdillon, \{Alexandra T.\} and Stapleton, \{Lyndsay M.\} and Anahita Eskandari and Fairman, \{Alexander S.\} and William Hiesinger and Esipova, \{Tatiana V.\} and Patrick, \{William L.\} and Keven Ji and Shizuru, \{Judith A.\} and Woo, \{Y. Joseph\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2017 The Authors, some rights reserved.",

year = "2017",

month = jun,

doi = "10.1126/sciadv.1603078",

language = "English",

volume = "3",

journal = "Science advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science",

number = "6",

}

Cohen, JE, Goldstone, AB, Paulsen, MJ, Shudo, Y, Steele, AN, Edwards, BB, Patel, JB, MacArthur, JW, Hopkins, MS, Burnett, CE, Jaatinen, KJ, Thakore, AD, Farry, JM, Truong, VN, Bourdillon, AT, Stapleton, LM, Eskandari, A, Fairman, AS, Hiesinger, W, Esipova, TV, Patrick, WL, Ji, K, Shizuru, JA & Woo, YJ 2017, 'An innovative biologic system for photon-powered myocardium in the ischemic heart', Science advances, vol. 3, no. 6, e1603078. https://doi.org/10.1126/sciadv.1603078

TY - JOUR

T1 - An innovative biologic system for photon-powered myocardium in the ischemic heart

AU - Cohen, Jeffrey E.

AU - Goldstone, Andrew B.

AU - Paulsen, Michael J.

AU - Shudo, Yasuhiro

AU - Steele, Amanda N.

AU - Edwards, Bryan B.

AU - Patel, Jay B.

AU - MacArthur, John W.

AU - Hopkins, Michael S.

AU - Burnett, Casey E.

AU - Jaatinen, Kevin J.

AU - Thakore, Akshara D.

AU - Farry, Justin M.

AU - Truong, Vi N.

AU - Bourdillon, Alexandra T.

AU - Stapleton, Lyndsay M.

AU - Eskandari, Anahita

AU - Fairman, Alexander S.

AU - Hiesinger, William

AU - Esipova, Tatiana V.

AU - Patrick, William L.

AU - Ji, Keven

AU - Shizuru, Judith A.

AU - Woo, Y. Joseph

PY - 2017/6

Y1 - 2017/6

N2 - Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium Synechococcus elongatus. By using light rather than blood flow as a source of energy, photosynthetic therapy increases tissue oxygenation, maintains myocardial metabolism, and yields durable improvements in cardiac function during and after induction of ischemia. By circumventing blood flow entirely to provide tissue with oxygen and nutrients, this system has the potential to create a paradigm shift in the way ischemic heart disease is treated.

AB - Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium Synechococcus elongatus. By using light rather than blood flow as a source of energy, photosynthetic therapy increases tissue oxygenation, maintains myocardial metabolism, and yields durable improvements in cardiac function during and after induction of ischemia. By circumventing blood flow entirely to provide tissue with oxygen and nutrients, this system has the potential to create a paradigm shift in the way ischemic heart disease is treated.

UR - https://www.scopus.com/pages/publications/85038440666

U2 - 10.1126/sciadv.1603078

DO - 10.1126/sciadv.1603078

M3 - Article

C2 - 28630913

AN - SCOPUS:85038440666

SN - 2375-2548

VL - 3

JO - Science advances

JF - Science advances

IS - 6

M1 - e1603078

ER -

An innovative biologic system for photon-powered myocardium in the ischemic heart

Abstract

Access to Document

Fingerprint

Cite this