TY - JOUR
T1 - An initial experience with FDG-PET in the imaging of residual disease after induction therapy for lung cancer
AU - Akhurst, Tim
AU - Downey, Robert J.
AU - Ginsberg, Michelle S.
AU - Gonen, Mithat
AU - Bains, Manjit
AU - Korst, Robert
AU - Ginsberg, Robert J.
AU - Rusch, Valerie W.
AU - Larson, Steven M.
N1 - Funding Information:
The authors thank Dr Nael Martini for reviewing the manuscript and providing his insightful comments. Supported in part by the Laurent and Alberta Gerschel Foundation.
PY - 2002
Y1 - 2002
N2 - Background. The 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) imaging is an advance over computed tomography alone in the staging of untreated nonsmall cell lung cancer (NSCLC). Aside from one 9-patient study, there are no data comparing FDG-PET imaging with surgical staging of NSCLC after induction therapy. Methods. We reviewed our institutional experience with FDG-PET imaging followed by surgical staging of nonsmall cell lung cancer after induction therapy. A nuclear physician blinded to surgical findings reviewed the FDG-PET scans and assigned a clinical TNM stage. A thoracic surgeon assigned a pathologic TNM stage. Then the clinical TNM stage and the pathologic TNM stage were compared. Results. Fifty-six patients (30 males and 26 females; median, age 60) with nonsmall cell lung cancer underwent chemotherapy (40 patients), chemoradiation (11 patients), or radiation alone (5 patients) followed by PET and operations. PET had a positive predictive value of 98% for detecting residual viable disease in the primary tumor. PET over-staged nodal status in 33% of patients, under staged nodal status in 15%, and was correct in 52%. PET correctly classified all patients with M1 disease. Conclusions. Positron emission tomography after induction therapy accurately detects residual viable primary tumor, but not the involvement of mediastinal lymph nodes.
AB - Background. The 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) imaging is an advance over computed tomography alone in the staging of untreated nonsmall cell lung cancer (NSCLC). Aside from one 9-patient study, there are no data comparing FDG-PET imaging with surgical staging of NSCLC after induction therapy. Methods. We reviewed our institutional experience with FDG-PET imaging followed by surgical staging of nonsmall cell lung cancer after induction therapy. A nuclear physician blinded to surgical findings reviewed the FDG-PET scans and assigned a clinical TNM stage. A thoracic surgeon assigned a pathologic TNM stage. Then the clinical TNM stage and the pathologic TNM stage were compared. Results. Fifty-six patients (30 males and 26 females; median, age 60) with nonsmall cell lung cancer underwent chemotherapy (40 patients), chemoradiation (11 patients), or radiation alone (5 patients) followed by PET and operations. PET had a positive predictive value of 98% for detecting residual viable disease in the primary tumor. PET over-staged nodal status in 33% of patients, under staged nodal status in 15%, and was correct in 52%. PET correctly classified all patients with M1 disease. Conclusions. Positron emission tomography after induction therapy accurately detects residual viable primary tumor, but not the involvement of mediastinal lymph nodes.
UR - https://www.scopus.com/pages/publications/0036148550
U2 - 10.1016/S0003-4975(01)03257-X
DO - 10.1016/S0003-4975(01)03257-X
M3 - Article
C2 - 11834020
AN - SCOPUS:0036148550
SN - 0003-4975
VL - 73
SP - 259
EP - 266
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 1
ER -