TY - JOUR
T1 - An evaluation of respiratory effects following exposure to 2.0 ppm formaldehyde in asthmatics
T2 - Lung function, symptoms, and airway reactivity
AU - Witek, T. J.
AU - Schachter, E.
AU - Tosun, T.
AU - Beck, G. J.
AU - Leaderer, B. P.
PY - 1987
Y1 - 1987
N2 - Fifteen asthmatic volunteers were exposed in a double-blind, random manner to room air and 2.0 ppm formaldehyde for 40 min in an environmental chamber. These exposures were repeated on a separate day during moderate exercise (450 kpm/min) for 10 min. Ambient and dew point temperatures were 23.0 ± 0.0°C 11.5 ± 1.0°C, respectively. No significant airway obstruction as measured by flow-volume parameters and airway resistance was noted in this group during or immediately after exposure. Furthermore, sequential measurements of peak flow for 24 hr following formaldehyde exposure revealed no delayed airway response. In contrast, in comparison to the baseline methacholine inhalation challenge (MIC) test on the screening day, 8 of 12 asthmatics demonstrated a lower threshold to MIC following 2.0 ppm exposure for 40 min; however, the mean and median decrements of theshold in methacholine concentration of 10.4 mg/ml and 24.3 mg/ml were not significant (p = .12). Bad odor, sore throat, and eye irritation were common during exposure but symptoms were infrequent afterward.
AB - Fifteen asthmatic volunteers were exposed in a double-blind, random manner to room air and 2.0 ppm formaldehyde for 40 min in an environmental chamber. These exposures were repeated on a separate day during moderate exercise (450 kpm/min) for 10 min. Ambient and dew point temperatures were 23.0 ± 0.0°C 11.5 ± 1.0°C, respectively. No significant airway obstruction as measured by flow-volume parameters and airway resistance was noted in this group during or immediately after exposure. Furthermore, sequential measurements of peak flow for 24 hr following formaldehyde exposure revealed no delayed airway response. In contrast, in comparison to the baseline methacholine inhalation challenge (MIC) test on the screening day, 8 of 12 asthmatics demonstrated a lower threshold to MIC following 2.0 ppm exposure for 40 min; however, the mean and median decrements of theshold in methacholine concentration of 10.4 mg/ml and 24.3 mg/ml were not significant (p = .12). Bad odor, sore throat, and eye irritation were common during exposure but symptoms were infrequent afterward.
UR - http://www.scopus.com/inward/record.url?scp=0023232743&partnerID=8YFLogxK
M3 - Article
C2 - 3310924
AN - SCOPUS:0023232743
SN - 0003-9896
VL - 42
SP - 230
EP - 237
JO - Archives of Environmental Health
JF - Archives of Environmental Health
IS - 4
ER -