An estrogen receptor genetic polymorphism and the risk of primary and secondary recurrent spontaneous abortion

Gertrud S. Berkowitz, Joanne L. Stone, Steven P. Lehrer, Michele Marcus, Robert H. Lapinski, Beth S. Schachter

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

OBJECTIVE: A case-control study was undertaken to assess the association between an estrogen receptor gene variant and the risk of recurrent spontaneous abortions. STUDY DESIGN: The frequency of the estrogen receptor gene variant in blood lymphocyte deoxyribonucleic acid and other selected maternal characteristics was compared among 60 primary recurrent aborters, 61 secondary recurrent aborters, and 43 women who had had at least two live births but no spontaneous abortions. RESULTS: No association was evident between the estrogen receptor gene variant and the risk of either primary or secondary recurrent abortion. There were data suggesting that primary recurrent aborters in particular were more likely to report a family history of recurrent abortion and a family history of breast cancer. CONCLUSIONS: These findings indicate that the estrogen receptor polymorphism is not a genetic marker for recurrent spontaneous abortions. Therefore, as suggested by previous investigations, this polymorphism appears to be a marker for breast cancer risk only among the subgroups who have had a history of repeated abortions.

Original languageEnglish
Pages (from-to)1579-1584
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume171
Issue number6
DOIs
StatePublished - Dec 1994
Externally publishedYes

Keywords

  • Abortion
  • estrogen
  • polymorphism
  • receptors

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