An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy

Yun Li, Jason A. Chen, Renee L. Sears, Fuying Gao, Eric D. Klein, Anna Karydas, Michael D. Geschwind, Howard J. Rosen, Adam L. Boxer, Weilong Guo, Matteo Pellegrini, Steve Horvath, Bruce L. Miller, Daniel H. Geschwind, Giovanni Coppola

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Little is known about how changes in DNA methylation mediate risk for human diseases including dementia. Analysis of genome-wide methylation patterns in patients with two forms of tau-related dementia - progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) - revealed significant differentially methylated probes (DMPs) in patients versus unaffected controls. Remarkably, DMPs in PSP were clustered within the 17q21.31 region, previously known to harbor the major genetic risk factor for PSP. We identified and replicated a dose-dependent effect of the risk-associated H1 haplotype on methylation levels within the region in blood and brain. These data reveal that the H1 haplotype increases risk for tauopathy via differential methylation at that locus, indicating a mediating role for methylation in dementia pathophysiology.

Original languageEnglish
Article numbere1004211
JournalPLoS Genetics
Volume10
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

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