An enzymatic system for removing heparin in extracorporeal therapy

Robert Langer; Robert J. Linhardt; Steven Hoffberg; Annette K. Larsen; Charles L. Cooney; David Tapper; Michael Klein

doi:10.1126/science.7089564

An enzymatic system for removing heparin in extracorporeal therapy

Robert Langer
, Robert J. Linhardt
, Steven Hoffberg
, Annette K. Larsen
, Charles L. Cooney
, David Tapper
, Michael Klein

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.

Original language	English
Pages (from-to)	261-263
Number of pages	3
Journal	Science
Volume	217
Issue number	4556
DOIs	https://doi.org/10.1126/science.7089564
State	Published - 1982
Externally published	Yes

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title = "An enzymatic system for removing heparin in extracorporeal therapy",

abstract = "The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.",

author = "Robert Langer and Linhardt, \{Robert J.\} and Steven Hoffberg and Larsen, \{Annette K.\} and Cooney, \{Charles L.\} and David Tapper and Michael Klein",

year = "1982",

doi = "10.1126/science.7089564",

language = "English",

volume = "217",

pages = "261--263",

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T1 - An enzymatic system for removing heparin in extracorporeal therapy

AU - Langer, Robert

AU - Linhardt, Robert J.

AU - Hoffberg, Steven

AU - Larsen, Annette K.

AU - Cooney, Charles L.

AU - Tapper, David

AU - Klein, Michael

PY - 1982

Y1 - 1982

N2 - The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.

AB - The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.

UR - https://www.scopus.com/pages/publications/0019944473

U2 - 10.1126/science.7089564

DO - 10.1126/science.7089564

M3 - Article

C2 - 7089564

AN - SCOPUS:0019944473

SN - 0036-8075

VL - 217

SP - 261

EP - 263

JO - Science

JF - Science

IS - 4556

ER -

An enzymatic system for removing heparin in extracorporeal therapy

Abstract

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