AN ELECTROENCEPHALOGRAPHIC INVESTIGATION OF SHORT‐TERM EFFECTS OF THREE HYPOTHALAMIC HORMONES (TRH, LH/FSH‐RH, GH‐RIH) IN NORMAL SUBJECTS

HEATHER ASHTON, J. E. MILLMAN, ROSEMARY TELFORD, J. W. THOMPSON, T. F. DAVIES, R. HALL

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Abstract

Three hypothalamic regulatory hormones, thyrotrophin‐releasing hormone (TRH), luteinizing hormone/follicle‐stimulating hormone‐releasing hormone (LH/FSH—RH) and growth hormone‐release inhibiting hormone (GH—RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative variation (CNV) in normal subjects. TRH was given as a 10 ml infusion of 600 μg over 8 min to six subjects. This produced subjective sensations and a rise in heart rate but no significant alteration of CNV magnitude. LH/FSH—RH was given in a dose of 200 μg in 10 ml over 2 min to six subjects. This had no effect on CNV magnitude or heart rate and produced no subjective effects. GH—RIH was given as a 10 ml infusion of 250 μg over 10 min to six subjects. Again there was no alteration in the magnitude of the CNV; the heart rate was slowed. 1976 The British Pharmacological Society

Original languageEnglish
Pages (from-to)523-531
Number of pages9
JournalBritish Journal of Clinical Pharmacology
Volume3
Issue number4
DOIs
StatePublished - Aug 1976
Externally publishedYes

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