An autoradiographic study of the development of [3H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system

P. R. Lowenstein; P. A. Slesinger; H. S. Singer; L. C. Walker; M. F. Casanova; D. L. Price; J. T. Coyle

doi:10.1016/0165-3806(87)90216-1

An autoradiographic study of the development of [³H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system

P. R. Lowenstein
, P. A. Slesinger
, H. S. Singer
, L. C. Walker
, M. F. Casanova
, D. L. Price
, J. T. Coyle

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The developmental distribution of the sodium-dependent high affinity choline uptake (SDHACU) system has been studied in the caudate and putamen of the baboon and of the human by in vitro autoradiography with the ligand, [³H]hemicholinium-3 ([³H]HCh3). Our results show that [³H]HCh3 binding sites in the newborn baboon and fetal human neostriatum are localized to patches, and then adopt a 'striosome-like' distribution in the juvenile baboon brain. These findings indicate a reorganization of [³H]HCh3 binding site distribution during the ontogeny of the primate neostriatum.

Original language	English
Pages (from-to)	291-297
Number of pages	7
Journal	Developmental Brain Research
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(87)90216-1
State	Published - Aug 1987
Externally published	Yes

Keywords

Baboon striatum
Basal ganglion
Choline uptake system
Development
[H]Hemicholinium binding

Access to Document

10.1016/0165-3806(87)90216-1

Cite this

Lowenstein, P. R., Slesinger, P. A., Singer, H. S., Walker, L. C., Casanova, M. F., Price, D. L., & Coyle, J. T. (1987). An autoradiographic study of the development of [³H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system. Developmental Brain Research, 34(2), 291-297. https://doi.org/10.1016/0165-3806(87)90216-1

@article{a9afe474bf594ceab60f40e6f07308e2,

title = "An autoradiographic study of the development of [3H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system",

abstract = "The developmental distribution of the sodium-dependent high affinity choline uptake (SDHACU) system has been studied in the caudate and putamen of the baboon and of the human by in vitro autoradiography with the ligand, [3H]hemicholinium-3 ([3H]HCh3). Our results show that [3H]HCh3 binding sites in the newborn baboon and fetal human neostriatum are localized to patches, and then adopt a 'striosome-like' distribution in the juvenile baboon brain. These findings indicate a reorganization of [3H]HCh3 binding site distribution during the ontogeny of the primate neostriatum.",

keywords = "Baboon striatum, Basal ganglion, Choline uptake system, Development, [H]Hemicholinium binding",

author = "Lowenstein, \{P. R.\} and Slesinger, \{P. A.\} and Singer, \{H. S.\} and Walker, \{L. C.\} and Casanova, \{M. F.\} and Price, \{D. L.\} and Coyle, \{J. T.\}",

note = "Funding Information: The authors thank Alice Trawinski for excellent secretarial assistance. This research was supported by USPHS Grants NS 13584, RSDA MH-00125, grants from the Mc Knight and Surdna Foundations to J.T.C., a Fogarty International Fellowship 1-FO5 TWO3447-01 to P.R.L. and USPHS Grants NS 20471 and AG 05146, and funds from the Robert L. and Clara G. Patterson Trust to D.L.P.",

year = "1987",

month = aug,

doi = "10.1016/0165-3806(87)90216-1",

language = "English",

volume = "34",

pages = "291--297",

journal = "Developmental Brain Research",

issn = "0165-3806",

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number = "2",

}

Lowenstein, PR, Slesinger, PA, Singer, HS, Walker, LC, Casanova, MF, Price, DL & Coyle, JT 1987, 'An autoradiographic study of the development of [³H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system', Developmental Brain Research, vol. 34, no. 2, pp. 291-297. https://doi.org/10.1016/0165-3806(87)90216-1

An autoradiographic study of the development of [³H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system. / Lowenstein, P. R.; Slesinger, P. A.; Singer, H. S. et al.
In: Developmental Brain Research, Vol. 34, No. 2, 08.1987, p. 291-297.

Research output: Contribution to journal › Article › peer-review

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T1 - An autoradiographic study of the development of [3H]hemicholinium-3 binding sites in human and baboon basal ganglia

T2 - a marker for the sodium-dependent high affinity choline uptake system

AU - Lowenstein, P. R.

AU - Slesinger, P. A.

AU - Singer, H. S.

AU - Walker, L. C.

AU - Casanova, M. F.

AU - Price, D. L.

AU - Coyle, J. T.

N1 - Funding Information: The authors thank Alice Trawinski for excellent secretarial assistance. This research was supported by USPHS Grants NS 13584, RSDA MH-00125, grants from the Mc Knight and Surdna Foundations to J.T.C., a Fogarty International Fellowship 1-FO5 TWO3447-01 to P.R.L. and USPHS Grants NS 20471 and AG 05146, and funds from the Robert L. and Clara G. Patterson Trust to D.L.P.

PY - 1987/8

Y1 - 1987/8

N2 - The developmental distribution of the sodium-dependent high affinity choline uptake (SDHACU) system has been studied in the caudate and putamen of the baboon and of the human by in vitro autoradiography with the ligand, [3H]hemicholinium-3 ([3H]HCh3). Our results show that [3H]HCh3 binding sites in the newborn baboon and fetal human neostriatum are localized to patches, and then adopt a 'striosome-like' distribution in the juvenile baboon brain. These findings indicate a reorganization of [3H]HCh3 binding site distribution during the ontogeny of the primate neostriatum.

AB - The developmental distribution of the sodium-dependent high affinity choline uptake (SDHACU) system has been studied in the caudate and putamen of the baboon and of the human by in vitro autoradiography with the ligand, [3H]hemicholinium-3 ([3H]HCh3). Our results show that [3H]HCh3 binding sites in the newborn baboon and fetal human neostriatum are localized to patches, and then adopt a 'striosome-like' distribution in the juvenile baboon brain. These findings indicate a reorganization of [3H]HCh3 binding site distribution during the ontogeny of the primate neostriatum.

KW - Baboon striatum

KW - Basal ganglion

KW - Choline uptake system

KW - Development

KW - [H]Hemicholinium binding

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DO - 10.1016/0165-3806(87)90216-1

M3 - Article

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AN - SCOPUS:0023274202

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JO - Developmental Brain Research

JF - Developmental Brain Research

IS - 2