An assessment by the statin muscle safety task force: 2014 update

Robert S. Rosenson, Steven K. Baker, Terry A. Jacobson, Stephen L. Kopecky, Beth A. Parker

Research output: Contribution to journalArticlepeer-review

364 Scopus citations

Abstract

The National Lipid Association's Muscle Safety Expert Panel was charged with the duty of examining the definitions for statin-associated muscle adverse events, development of a clinical index to assess myalgia, and the use of diagnostic neuromuscular studies to investigate muscle adverse events. We provide guidance as to when a patient should be considered for referral to neuromuscular specialists and indications for the performance of a skeletal muscle biopsy. Based on this review of evidence, we developed an algorithm for the evaluation and treatment of patients who may be intolerant to statins as the result of adverse muscle events. The panel was composed of clinical cardiologists, clinical lipidologists, an exercise physiologist, and a neuromuscular specialist.

Original languageEnglish
Pages (from-to)S58-S71
JournalJournal of Clinical Lipidology
Volume8
Issue number3 SUPPL
DOIs
StatePublished - 2014

Keywords

  • Muscle adverse events
  • Myalgia
  • Myopathy
  • Neuromuscular testing
  • Rhabdomyolysis
  • Statin intolerance
  • Statins

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