Amyloid in dementia associated with familial FTLD: not an innocent bystander

Georges Naasan, Gil D. Rabinovici, Pia Ghosh, Jonathan D. Elofson, Bruce L. Miller, Giovanni Coppola, Anna Karydas, Jamie Fong, David Perry, Suzee E. Lee, Jennifer S. Yokoyama, William W. Seeley, Joel H. Kramer, Michael W. Weiner, Norbert Schuff, William J. Jagust, Lea T. Grinberg, Mochtar Pribadi, Zhongan Yang, Renee SearsEric Klein, Kevin Wojta, Howard J. Rosen

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case–control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer’s disease-like pattern of neurodegeneration.

Original languageEnglish
Pages (from-to)76-83
Number of pages8
Issue number1
StatePublished - 2 Jan 2016
Externally publishedYes


  • Alzheimer’s disease
  • MRI
  • amyloid
  • frontotemporal dementia


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