@article{60faca12c0794d76ad523c2919e6bb6b,
title = "Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia",
abstract = "Alzheimer's disease (AD) has been associated with functional alterations in a distributed network of brain regions linked to memory function, with a recent focus on the cortical regions collectively known as the default network. Posterior components of the default network, including the precuneus and posterior cingulate, are particularly vulnerable to early deposition of amyloid β-protein, one of the hallmark pathologies of AD. In this study, we use in vivo amyloid imaging to demonstrate that high levels of amyloid deposition are associated with aberrant default network functional magnetic resonance imaging (fMRI) activity in asymptomatic and minimally impaired older individuals, similar to the pattern of dysfunction reported in AD patients. These findings suggest that amyloid pathology is linked to neural dysfunction in brain regions supporting memory function and provide support for the hypothesis that cognitively intact older individuals with evidence of amyloid pathology may be in early stages of AD.",
keywords = "HUMDISEASE, MOLNEURO, SYSNEURO",
author = "Sperling, {Reisa A.} and LaViolette, {Peter S.} and Kelly O'Keefe and Jacqueline O'Brien and Rentz, {Dorene M.} and Maija Pihlajamaki and Gad Marshall and Hyman, {Bradley T.} and Selkoe, {Dennis J.} and Trey Hedden and Buckner, {Randy L.} and Becker, {J. Alex} and Johnson, {Keith A.}",
note = "Funding Information: We thank Mary Foley, Larry White, and the Athinoula A. Martinos Center MRI Core for assistance with MRI imaging. The Massachusetts General Hospital Molecular Imaging PET Core provided assistance with PiB PET amyloid imaging. Bill Klunk and Chet Mathis from the University of Pittsburgh generously provided expertise in PiB imaging and analyses. We thank the Massaschusetts Alzheimer's Disease Research Center (ADRC) and Sarah Rastegar for assistance with subject recruitment. We thank Meghan Frey, Elisha Eng, and Lauren Olson for assistance with neuropsychological testing. We thank Bill Klunk, Brad Dickerson, Akram Bakkour, Deborah Blacker, Ali Atri, and Patrizia Vannini for assistance with analyses and insightful comments. This work was supported by the National Institute on Aging R01AG027435 (R.A.S. and K.A.J.), the Massachusetts Alzheimer's Disease Research Center P50AG005134 (R.A.S., K.A.J., B.T.H., D.J.S.), an Anonymous Medical Foundation (R.A.S.), the Howard Hughes Medical Institute (R.L.B.), and the Alzheimer's Association (R.A.S.). Dr. Keith Johnson has consulted for GE Healthcare, who holds the commercial licensing and distribution rights for PiB PET imaging. ",
year = "2009",
month = jul,
day = "30",
doi = "10.1016/j.neuron.2009.07.003",
language = "English",
volume = "63",
pages = "178--188",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}