Amyloid-beta plaque growth in cognitively normal adults: Longitudinal [ 11C]Pittsburgh compound B data

Andrei G. Vlassenko, Mark A. Mintun, Chengjie Xiong, Yvette I. Sheline, Alison M. Goate, Tammie L.S. Benzinger, John C. Morris

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

Amyloid-beta (Aβ) accumulation was evaluated with 2 [ 11C]Pittsburgh compound B (PiB) positron emission tomography scans about 2.5 years apart in 146 cognitively normal adults. Seventeen of 21 participants with initially elevated Aβ deposition demonstrated subsequent Aβ plaque growth (approximately 8.0% per year), and none reverted to a state of no Aβ deposits. Ten individuals converted from negative to positive PiB status, based on a threshold of the mean cortical binding potential, representing a conversion rate of 3.1% per year. Individuals with an Îμ4 allele of apolipoprotein E demonstrated increased incidence of conversion (7.0% per year). Our findings suggest that the major growth in Aβ burden occurs during a preclinical stage of Alzheimer disease (AD), prior to the onset of AD-related symptoms.

Original languageEnglish
Pages (from-to)857-861
Number of pages5
JournalAnnals of Neurology
Volume70
Issue number5
DOIs
StatePublished - Nov 2011
Externally publishedYes

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