@article{80e598c9888d48238ea8004f7b9051b9,
title = "Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults",
abstract = "In the present study, we tested the hypothesis that higher amyloid-beta (Aβ) burden at baseline is associated with greater longitudinal decline in body mass index (BMI) in clinically normal adults. Participants from the Harvard Aging Brain Study (n = 312) and the Alzheimer's Disease Neuroimaging Initiative (n = 336) underwent Aβ positron emission tomography at baseline. BMI was assessed longitudinally over a median of >4 years. Linear mixed models showed that higher baseline Aβ burden was significantly associated with greater decline in BMI in both the Harvard Aging Brain Study (t = −1.93; p = 0.05) and Alzheimer's Disease Neuroimaging Initiative cohorts (t = −2.54; p = 0.01), after adjusting for covariates, including cognitive performance and depressive symptoms. In addition, the association of Aβ burden with longitudinal decline in BMI persisted in both cohorts after excluding participants with diabetes/endocrine disturbances and participants classified as underweight or obese (BMI <18.5 or >30). These findings suggest that decline in BMI in clinically normal adults may be an early manifestation related to cerebral amyloidosis that precedes objective cognitive impairment. Therefore, unintentional BMI decline in otherwise healthy individuals might alert clinicians to increased risk of Alzheimer's disease.",
keywords = "ADNI, Amyloid-beta, Body mass index, HABS, Longitudinal, Preclinical Alzheimer's disease, Weight loss",
author = "{Harvard Aging Brain Study} and {Alzheimer's Disease Neuroimaging Initiative} and Rabin, {Jennifer S.} and Zahra Shirzadi and Walter Swardfager and MacIntosh, {Bradley J.} and Aaron Schultz and Yang, {Hyun Sik} and Buckley, {Rachel F.} and Gatchel, {Jennifer R.} and Dylan Kirn and Pruzin, {Jeremy J.} and Trey Hedden and Nir Lipsman and Rentz, {Dorene M.} and Black, {Sandra E.} and Johnson, {Keith A.} and Sperling, {Reisa A.} and Chhatwal, {Jasmeer P.}",
note = "Funding Information: Some data used in the preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). The ADNI (www.adni.loni.usc.edu) was launched in 2003 as a public-private partnership, led by Principal Investigator Michael W. Weiner, MD. The primary goal of ADNI has been to test whether serial magnetic resonance imaging (MRI), positron emission tomography (PET), other biological markers, and clinical and neuropsychological assessment can be combined to measure the progression of MCI and early AD. For up-to-date information, see www.adni-info.org/. This work was supported by the National Institute on Aging (NIA) at the National Institutes of Health (NIH) (P01 AG036694 to R.A.S. and K.A.J. K24 AG035007 to R.A.S. K23 AG049087 to J.P.C. R01 AG053509 and R01 AG054110 to T.H, and P50 AG005134 to R.A.S. K.A.J. and T.H. J.S.R. was supported by a Canadian Institutes of Health Research Postdoctoral Fellowship Award, H.-S.Y. is supported by NIA/NIH K23 AG062750; R.F.B. is supported by the NHMRC Dementia Research Fellowship (APP1105576). J.R.G. is supported by NIA/NIH K23 AG058805, AACF-16-440965 and BrightFocus Foundation ADRF A2016434 F. W.S. is supported by the Alzheimer's Association and Brain Canada (AARG501466). Funding Information: This work was supported by the National Institute on Aging (NIA) at the National Institutes of Health (NIH) ( P01 AG036694 to R.A.S. and K.A.J., K24 AG035007 to R.A.S., K23 AG049087 to J.P.C., R01 AG053509 and R01 AG054110 to T.H, and P50 AG005134 to R.A.S., K.A.J., and T.H. J.S.R. was supported by a Canadian Institutes of Health Research Postdoctoral Fellowship Award , H.-S.Y. is supported by NIA/NIH K23 AG062750 ; R.F.B. is supported by the NHMRC Dementia Research Fellowship ( APP1105576 ). J.R.G. is supported by NIA/NIH K23 AG058805, AACF-16-440965 and BrightFocus Foundation ADRF A2016434 F. W.S. is supported by the Alzheimer{\textquoteright}s Association and Brain Canada ( AARG501466 ). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = sep,
doi = "10.1016/j.neurobiolaging.2020.03.002",
language = "English",
volume = "93",
pages = "124--130",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
}