TY - JOUR
T1 - Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease
AU - Dominantly Inherited Alzheimer Network (DIAN)
AU - PREVENT-AD Research Group
AU - Pichet Binette, Alexa
AU - Vachon-Presseau, Étienne
AU - Morris, John C.
AU - Bateman, Randall J.
AU - Benzinger, Tammie
AU - Collins, D. Louis
AU - Poirier, Judes
AU - Breitner, John C.S.
AU - Villeneuve, Sylvia
AU - Allegri, Ricardo
AU - Amtashar, Fatima
AU - Berman, Sarah
AU - Bodge, Courtney
AU - Brandon, Susan
AU - Brooks, William (Bill)
AU - Buck, Jill
AU - Buckles, Virginia
AU - Chea, Sochenda
AU - Chhatwal, Jasmeer
AU - Chrem, Patricio
AU - Chui, Helena
AU - Cinco, Jake
AU - Clifford, Jack
AU - Cruchaga, Carlos
AU - D‘Mello, Mirelle
AU - Donahue, Tamara
AU - Douglas, Jane
AU - Edigo, Noelia
AU - Erekin-Taner, Nilufer
AU - Fagan, Anne
AU - Farlow, Marty
AU - Farrar, Angela
AU - Feldman, Howard
AU - Flynn, Gigi
AU - Fox, Nick
AU - Franklin, Erin
AU - Fujii, Hisako
AU - Gant, Cortaiga
AU - Gardener, Samantha
AU - Ghetti, Bernardino
AU - Goate, Alison
AU - Goldman, Jill
AU - Gordon, Brian
AU - Graff-Radford, Neill
AU - Gray, Julia
AU - Gurney, Jenny
AU - Hassenstab, Jason
AU - Hirohara, Mie
AU - Holtzman, David
AU - Wang, Jen
N1 - Publisher Copyright:
© 2020 Society of Biological Psychiatry
PY - 2021/4/15
Y1 - 2021/4/15
N2 - Background: Major prevention trials for Alzheimer's disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined which combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle (years of education or lifetime cognitive activity) related to the pathological hallmarks of AD, amyloid-β, and tau deposits. Methods: A total of 115 older adults with a parental or multiple-sibling family history of sporadic AD (PREVENT-AD [PRe-symptomatic EValuation of Experimental or Novel Treatments for AD] cohort) underwent amyloid and tau positron emission tomography and answered several questionnaires related to behavioral attributes. Separately, we studied 117 mutation carriers from the DIAN (Dominant Inherited Alzheimer Network) study group cohort with amyloid positron emission tomography and behavioral data. Using partial least squares analysis, we identified latent variables relating amyloid or tau pathology with combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle. Results: In PREVENT-AD, lower neuroticism, neuropsychiatric burden, and higher education were associated with less amyloid deposition (p =.014). Lower neuroticism and neuropsychiatric features, along with higher measures of openness and extraversion, were related to less tau deposition (p =.006). In DIAN, lower neuropsychiatric burden and higher education were also associated with less amyloid (p =.005). The combination of these factors accounted for up to 14% of AD pathology. Conclusions: In the preclinical phase of both sporadic and autosomal dominant AD, multiple behavioral features were associated with AD pathology. These results may suggest potential pathways by which multidomain interventions might help delay AD onset or progression.
AB - Background: Major prevention trials for Alzheimer's disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined which combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle (years of education or lifetime cognitive activity) related to the pathological hallmarks of AD, amyloid-β, and tau deposits. Methods: A total of 115 older adults with a parental or multiple-sibling family history of sporadic AD (PREVENT-AD [PRe-symptomatic EValuation of Experimental or Novel Treatments for AD] cohort) underwent amyloid and tau positron emission tomography and answered several questionnaires related to behavioral attributes. Separately, we studied 117 mutation carriers from the DIAN (Dominant Inherited Alzheimer Network) study group cohort with amyloid positron emission tomography and behavioral data. Using partial least squares analysis, we identified latent variables relating amyloid or tau pathology with combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle. Results: In PREVENT-AD, lower neuroticism, neuropsychiatric burden, and higher education were associated with less amyloid deposition (p =.014). Lower neuroticism and neuropsychiatric features, along with higher measures of openness and extraversion, were related to less tau deposition (p =.006). In DIAN, lower neuropsychiatric burden and higher education were also associated with less amyloid (p =.005). The combination of these factors accounted for up to 14% of AD pathology. Conclusions: In the preclinical phase of both sporadic and autosomal dominant AD, multiple behavioral features were associated with AD pathology. These results may suggest potential pathways by which multidomain interventions might help delay AD onset or progression.
KW - Alzheimer's
KW - PET
KW - Prevention
KW - Reserve
KW - Resistance
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85082547156&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2020.01.023
DO - 10.1016/j.biopsych.2020.01.023
M3 - Article
C2 - 32228870
AN - SCOPUS:85082547156
SN - 0006-3223
VL - 89
SP - 776
EP - 785
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 8
ER -