AMPT effects on cue-induced craving for cocaine

Ismene L. Petrakis, Sally L. Satel, Susan Stine, Thomas R. Kosten, Sheila N. Namanworth, Dennis S. Charney, John H. Krystal

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The authors evaluated the effect of an acute reduction in catecholamine synthesis, produced by alpha methyl para tyrosine (AMPT), on cue-induced craving for cocaine in cocaine-dependent patients. AMPT and diphenhydramine were administered under double-blind conditions in a randomized, crossover design. Two cue exposure sessions were conducted 1 week apart. Self-reported assessments of cocaine craving were administered before and after cue exposure. AMPT, but not diphenhydramine, significantly decreased plasma levels of the dopamine metabolite, homovanillic acid and the norepinephrine metabolite, 3-methoxy-4-hydroxy phenylethylene glycol. However, AMPT's effects on cue-induced craving interacted with the test-day order in a complex manner.

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalAmerican Journal on Addictions
Volume5
Issue number4
DOIs
StatePublished - 1996
Externally publishedYes

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