TY - JOUR
T1 - AMPT effects on cue-induced craving for cocaine
AU - Petrakis, Ismene L.
AU - Satel, Sally L.
AU - Stine, Susan
AU - Kosten, Thomas R.
AU - Namanworth, Sheila N.
AU - Charney, Dennis S.
AU - Krystal, John H.
PY - 1996
Y1 - 1996
N2 - The authors evaluated the effect of an acute reduction in catecholamine synthesis, produced by alpha methyl para tyrosine (AMPT), on cue-induced craving for cocaine in cocaine-dependent patients. AMPT and diphenhydramine were administered under double-blind conditions in a randomized, crossover design. Two cue exposure sessions were conducted 1 week apart. Self-reported assessments of cocaine craving were administered before and after cue exposure. AMPT, but not diphenhydramine, significantly decreased plasma levels of the dopamine metabolite, homovanillic acid and the norepinephrine metabolite, 3-methoxy-4-hydroxy phenylethylene glycol. However, AMPT's effects on cue-induced craving interacted with the test-day order in a complex manner.
AB - The authors evaluated the effect of an acute reduction in catecholamine synthesis, produced by alpha methyl para tyrosine (AMPT), on cue-induced craving for cocaine in cocaine-dependent patients. AMPT and diphenhydramine were administered under double-blind conditions in a randomized, crossover design. Two cue exposure sessions were conducted 1 week apart. Self-reported assessments of cocaine craving were administered before and after cue exposure. AMPT, but not diphenhydramine, significantly decreased plasma levels of the dopamine metabolite, homovanillic acid and the norepinephrine metabolite, 3-methoxy-4-hydroxy phenylethylene glycol. However, AMPT's effects on cue-induced craving interacted with the test-day order in a complex manner.
UR - http://www.scopus.com/inward/record.url?scp=0029798407&partnerID=8YFLogxK
U2 - 10.1111/j.1521-0391.1996.tb00317.x
DO - 10.1111/j.1521-0391.1996.tb00317.x
M3 - Article
AN - SCOPUS:0029798407
SN - 1055-0496
VL - 5
SP - 313
EP - 320
JO - American Journal on Addictions
JF - American Journal on Addictions
IS - 4
ER -