Amphetamine enhances extracellular concentrations of dopamine and acetylcholine in dorsolateral striatum and nucleus accumbens of freely moving rats

Teresa Guix; Yasmin L. Hurd; Urban Ungerstedt

doi:10.1016/0304-3940(92)90490-X

Amphetamine enhances extracellular concentrations of dopamine and acetylcholine in dorsolateral striatum and nucleus accumbens of freely moving rats

Teresa Guix
, Yasmin L. Hurd
, Urban Ungerstedt

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

The effect of two consecutive administrations of amphetamine (1.5 mg/kg, s.c.; 2 h apart) on dopamine (DA) and acetylcholine (ACh) efflux in dorsolateral striatum and nucleus accumbens was studied with in vivo microdialysis in freely moving rats. Amphetamine was found to cause a more persistent increase of extracellular DA in the dorsolateral striatum than in the nucleus accumbens. The increase in DA overflow by amphetamine was accompanied by an increase of extracellular ACh in both brain areas. The results are inconsistent with the hypothesis of an amphetamine-induced inhibitory regulation by DA on ACh overflow.

Original language	English
Pages (from-to)	137-140
Number of pages	4
Journal	Neuroscience Letters
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(92)90490-X
State	Published - 13 Apr 1992
Externally published	Yes

Keywords

Acetylcholine
Amphetamine
Dopamine
In vivo microdialysis

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10.1016/0304-3940(92)90490-X

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title = "Amphetamine enhances extracellular concentrations of dopamine and acetylcholine in dorsolateral striatum and nucleus accumbens of freely moving rats",

abstract = "The effect of two consecutive administrations of amphetamine (1.5 mg/kg, s.c.; 2 h apart) on dopamine (DA) and acetylcholine (ACh) efflux in dorsolateral striatum and nucleus accumbens was studied with in vivo microdialysis in freely moving rats. Amphetamine was found to cause a more persistent increase of extracellular DA in the dorsolateral striatum than in the nucleus accumbens. The increase in DA overflow by amphetamine was accompanied by an increase of extracellular ACh in both brain areas. The results are inconsistent with the hypothesis of an amphetamine-induced inhibitory regulation by DA on ACh overflow.",

keywords = "Acetylcholine, Amphetamine, Dopamine, In vivo microdialysis",

author = "Teresa Guix and Hurd, \{Yasmin L.\} and Urban Ungerstedt",

note = "Funding Information: This work was supportedb y a grants from CIRIT (Generalitatd e Catalunya).W e are deeply indebtedt o Ms. Ase Halltriim. Ms. Monica Karlsson and Dr. Sergi Ferrt for their assistancein all levelso f the study.",

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doi = "10.1016/0304-3940(92)90490-X",

language = "English",

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T1 - Amphetamine enhances extracellular concentrations of dopamine and acetylcholine in dorsolateral striatum and nucleus accumbens of freely moving rats

AU - Guix, Teresa

AU - Hurd, Yasmin L.

AU - Ungerstedt, Urban

N1 - Funding Information: This work was supportedb y a grants from CIRIT (Generalitatd e Catalunya).W e are deeply indebtedt o Ms. Ase Halltriim. Ms. Monica Karlsson and Dr. Sergi Ferrt for their assistancein all levelso f the study.

PY - 1992/4/13

Y1 - 1992/4/13

N2 - The effect of two consecutive administrations of amphetamine (1.5 mg/kg, s.c.; 2 h apart) on dopamine (DA) and acetylcholine (ACh) efflux in dorsolateral striatum and nucleus accumbens was studied with in vivo microdialysis in freely moving rats. Amphetamine was found to cause a more persistent increase of extracellular DA in the dorsolateral striatum than in the nucleus accumbens. The increase in DA overflow by amphetamine was accompanied by an increase of extracellular ACh in both brain areas. The results are inconsistent with the hypothesis of an amphetamine-induced inhibitory regulation by DA on ACh overflow.

AB - The effect of two consecutive administrations of amphetamine (1.5 mg/kg, s.c.; 2 h apart) on dopamine (DA) and acetylcholine (ACh) efflux in dorsolateral striatum and nucleus accumbens was studied with in vivo microdialysis in freely moving rats. Amphetamine was found to cause a more persistent increase of extracellular DA in the dorsolateral striatum than in the nucleus accumbens. The increase in DA overflow by amphetamine was accompanied by an increase of extracellular ACh in both brain areas. The results are inconsistent with the hypothesis of an amphetamine-induced inhibitory regulation by DA on ACh overflow.

KW - Acetylcholine

KW - Amphetamine

KW - Dopamine

KW - In vivo microdialysis

UR - https://www.scopus.com/pages/publications/0026555542

U2 - 10.1016/0304-3940(92)90490-X

DO - 10.1016/0304-3940(92)90490-X

M3 - Article

C2 - 1407652

AN - SCOPUS:0026555542

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VL - 138

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Amphetamine enhances extracellular concentrations of dopamine and acetylcholine in dorsolateral striatum and nucleus accumbens of freely moving rats

Abstract

Keywords

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