Amniotic Membrane Patching to Assist Closure of Recalcitrant Macular Holes

Jessica Lee, Michael Chua, Michael Jansen, Jerome Giovinazzo, Brittany Powell, Avnish Deobhakta, Amanda Wong, Daniel Zhu, Philip J. Ferrone, Ronald Gentile, Gennady Landa, Alan Dayan, Aryeh Pollack, Richard Rosen

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND OBJECTIVE: This study reports a case series of patients with persistent macular holes (MHs) who underwent human amniotic membrane subretinal placement to achieve successful anatomic MH closure. PATIENTS AND METHODS: This was a retrospective case series of patients with persistently open full-thickness MHs who underwent human amniotic membrane placement. Patients were observed up to 6 months postoperatively. RESULTS: Ten patients were included. The mean preoperative best-corrected visual acuity was 1.6 logMAR (20/800). Postoperatively, mean best-corrected visual acuity improved to 1.3 logMAR (20/400) at 1 month and 1.1 logMAR (20/250) by the 3- and 6-month visits. In all cases, the MH appeared closed at the 1-week visit and remained closed at their last follow-up. Optical coherence tomography showed closure in all cases. No adverse events were reported. CONCLUSIONS: Human amniotic membrane subretinal placement may serve as a useful surgical technique to assist in the closure of recalcitrant macular holes.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalOphthalmic Surgery Lasers and Imaging Retina
Issue number4
StatePublished - Apr 2023
Externally publishedYes


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