Amniotic fluid platelet factor 4 and beta-thromboglobulin as markers of structural abnormalities

Abdelaziz A. Saleh, Tsunenori Ozawa, Nelson B. Isada, Mark Paul Johnson, Mitchell P. Dombrowski, Mark I. Evans, Marjorie B. Treadwell, Eberhard F. Mammen

Research output: Contribution to journalArticlepeer-review


Platelet factor 4 (PF4) and β-thromboglobulin (BTG) are unique markers of irreversible platelet activation. We measured PF4 and BTG in amniotic fluid from 102 genetic amniocenteses, in which 78 had normal amniotic fluid a-feto-protein (AFP) levels with normal pregnancies, and 24 had high amniotic fluid AFP levels with abnormal pregnancies. PF4 and BTG were significantly higher in the abnormal pregnancy/elevated amniotic fluid AFP group (p < 0.002 in each case) and correlated with AFP expressed as multiples of the median (p < 0.05 and p < 0.0001, respectively). Our results are compatible with passage of PF4 and BTG across fetal membranes and/or enhanced fetal platelet activation in fetuses with structural anomalies and elevated AFP.

Original languageEnglish
Pages (from-to)175-177
Number of pages3
JournalFetal Diagnosis and Therapy
Issue number3
StatePublished - 1993
Externally publishedYes


  • Endothelium
  • Fetal
  • Fetal platelet function
  • Genetic amniocentesis
  • Platelet factor 4
  • α-Fetoprotein
  • β-Thromboglobulin


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