Amnesic syndrome with bilateral mesial temporal lobe involvement in Hashimoto's encephalopathy

Dominick J.H. McCabe, Teresa Burke, Sean Connolly, Michael Hutchinson

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

A 25-year-old woman presented with a subacute confusional state, headaches, unsteadiness, myoclonus, seizures, and an amnesic syndrome as a manifestation of Hashimoto's encephalopathy. Investigations showed biochemical hypothyroidism, raised thyroid microsomal antibodies, and weakly positive antineuronal antibodies. A T2-weighted MRI of the brain showed bilateral symmetric areas of increased signal in the mesial temporal lobes and hippocampi that had a low signal intensity on T1-weighted imaging. Despite clinical and radiologic improvement after steroid and thyroid hormone replacement therapy, a severe amnesic syndrome with associated localized MRI abnormalities persists.

Original languageEnglish
Pages (from-to)737-739
Number of pages3
JournalNeurology
Volume54
Issue number3
DOIs
StatePublished - 8 Feb 2000
Externally publishedYes

Keywords

  • Amnesic syndrome
  • Hashimoto's encephalopathy
  • MRI

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