Amnesic syndrome after theophylline associated seizures: Iatrogenic brain injury

J. I. O'Riordan, J. Hutchinson, M. X. FitzGerald, M. Hutchinson

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Two patients developed a disabling amnesic syndrome after seizures associated with oral theophylline treatment. Such seizures are more likely in the elderly, in the presence of pre-existing neurological disease, and when theophylline is given with certain antibiotics and cimetidine. The mechanism of neuronal injury may be by the excessive release of endogenous excitotoxic glutamate.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume57
Issue number5
DOIs
StatePublished - 1994
Externally publishedYes

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