Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses

Lijun Song; Sherwin Wilk; Dennis P. Healy

doi:10.1016/S0006-8993(96)00952-3

Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses

Lijun Song, Sherwin Wilk, Dennis P. Healy

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Angiotensin II increases drinking and blood pressure when administered intracerebroventricularly. Intracerebroventricular injections of antiserum with anticatalytic activity against aminopeptidase A, the principal enzyme that metabolizes angiotensin II to angiotensin III, reduced the drinking and blood pressure responses to 10 pmol angiotensin 11 by 73% and 59%, respectively. APA antiserum had no effect on responses to angiotensin III administered intracerebroventricularly. A Glu-thiol inhibitor of aminopeptidase A also reduced angiotensin II-induced drinking. These results suggest that metabolism of angiotensin II to angiotensin III is an obligatory activation step for the brain angiotensin system.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Brain Research
Volume	744
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(96)00952-3
State	Published - 2 Jan 1997
Externally published	Yes

Keywords

aminopeptidase A
aminopeptidase N
angiotensin II
angiotensin III
anticatalytic
blood pressure
dipsogenesis

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10.1016/S0006-8993(96)00952-3

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title = "Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses",

abstract = "Angiotensin II increases drinking and blood pressure when administered intracerebroventricularly. Intracerebroventricular injections of antiserum with anticatalytic activity against aminopeptidase A, the principal enzyme that metabolizes angiotensin II to angiotensin III, reduced the drinking and blood pressure responses to 10 pmol angiotensin 11 by 73% and 59%, respectively. APA antiserum had no effect on responses to angiotensin III administered intracerebroventricularly. A Glu-thiol inhibitor of aminopeptidase A also reduced angiotensin II-induced drinking. These results suggest that metabolism of angiotensin II to angiotensin III is an obligatory activation step for the brain angiotensin system.",

keywords = "aminopeptidase A, aminopeptidase N, angiotensin II, angiotensin III, anticatalytic, blood pressure, dipsogenesis",

author = "Lijun Song and Sherwin Wilk and Healy, {Dennis P.}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health (HL42585, HL50685, and NS17392). ",

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T1 - Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses

AU - Song, Lijun

AU - Wilk, Sherwin

AU - Healy, Dennis P.

N1 - Funding Information: This work was supported by grants from the National Institutes of Health (HL42585, HL50685, and NS17392).

PY - 1997/1/2

Y1 - 1997/1/2

N2 - Angiotensin II increases drinking and blood pressure when administered intracerebroventricularly. Intracerebroventricular injections of antiserum with anticatalytic activity against aminopeptidase A, the principal enzyme that metabolizes angiotensin II to angiotensin III, reduced the drinking and blood pressure responses to 10 pmol angiotensin 11 by 73% and 59%, respectively. APA antiserum had no effect on responses to angiotensin III administered intracerebroventricularly. A Glu-thiol inhibitor of aminopeptidase A also reduced angiotensin II-induced drinking. These results suggest that metabolism of angiotensin II to angiotensin III is an obligatory activation step for the brain angiotensin system.

AB - Angiotensin II increases drinking and blood pressure when administered intracerebroventricularly. Intracerebroventricular injections of antiserum with anticatalytic activity against aminopeptidase A, the principal enzyme that metabolizes angiotensin II to angiotensin III, reduced the drinking and blood pressure responses to 10 pmol angiotensin 11 by 73% and 59%, respectively. APA antiserum had no effect on responses to angiotensin III administered intracerebroventricularly. A Glu-thiol inhibitor of aminopeptidase A also reduced angiotensin II-induced drinking. These results suggest that metabolism of angiotensin II to angiotensin III is an obligatory activation step for the brain angiotensin system.

KW - aminopeptidase A

KW - aminopeptidase N

KW - angiotensin II

KW - angiotensin III

KW - anticatalytic

KW - blood pressure

KW - dipsogenesis

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Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses

Abstract

Keywords

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