TY - JOUR
T1 - American Society of Clinical Oncology Guideline
T2 - Recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer
AU - Lyman, Gary H.
AU - Khorana, Alok A.
AU - Falanga, Anna
AU - Clarke-Pearson, Daniel
AU - Flowers, Christopher
AU - Jahanzeb, Mohammad
AU - Kakkar, Ajay
AU - Kuderer, Nicole M.
AU - Levine, Mark N.
AU - Liebman, Howard
AU - Mendelson, David
AU - Raskob, Gary
AU - Somerfield, Mark R.
AU - Thodiyil, Paul
AU - Trent, David
AU - Francis, Charles W.
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Purpose: To develop guideline recommendations for the use of anticoagulation in the prevention and treatment of venous thromboembolism (VTE) in patients with cancer. Methods: A comprehensive systematic review of the medical literature on the prevention and treatment of VTE in cancer patients was conducted and reviewed by a panel of content and methodology experts. Following discussion of the results, the panel drafted recommendations for the use of anticoagulation in patients with malignant disease. Results: The results of randomized controlled trials of primary and secondary VTE medical prophylaxis, surgical prophylaxis, VTE treatment, and the impact of anticoagulation on survival of patients with cancer were reviewed. Recommendations were developed on the prevention of VTE in hospitalized, ambulatory, and surgical cancer patients as well as patients with established VTE, and for use of anticoagulants in cancer patients without VTE to improve survival. Conclusion: Recommendations of the American Society of Clinical Oncology VTE Guideline Panel include (1) all hospitalized cancer patients should be considered for VTE prophylaxis with anticoagulants in the absence of bleeding or other contraindications; (2) routine prophylaxis of ambulatory cancer patients with anticoagulation is not recommended, with the exception of patients receiving thalidomide or lenalidomide; (3) patients undergoing major surgery for malignant disease should be considered for pharmacologic thromboprophylaxis; (4) low molecular weight heparin represents the preferred agent for both the initial and continuing treatment of cancer patients with established VTE; and (5) the impact of anticoagulants on cancer patient survival requires additional study and cannot be recommended at present.
AB - Purpose: To develop guideline recommendations for the use of anticoagulation in the prevention and treatment of venous thromboembolism (VTE) in patients with cancer. Methods: A comprehensive systematic review of the medical literature on the prevention and treatment of VTE in cancer patients was conducted and reviewed by a panel of content and methodology experts. Following discussion of the results, the panel drafted recommendations for the use of anticoagulation in patients with malignant disease. Results: The results of randomized controlled trials of primary and secondary VTE medical prophylaxis, surgical prophylaxis, VTE treatment, and the impact of anticoagulation on survival of patients with cancer were reviewed. Recommendations were developed on the prevention of VTE in hospitalized, ambulatory, and surgical cancer patients as well as patients with established VTE, and for use of anticoagulants in cancer patients without VTE to improve survival. Conclusion: Recommendations of the American Society of Clinical Oncology VTE Guideline Panel include (1) all hospitalized cancer patients should be considered for VTE prophylaxis with anticoagulants in the absence of bleeding or other contraindications; (2) routine prophylaxis of ambulatory cancer patients with anticoagulation is not recommended, with the exception of patients receiving thalidomide or lenalidomide; (3) patients undergoing major surgery for malignant disease should be considered for pharmacologic thromboprophylaxis; (4) low molecular weight heparin represents the preferred agent for both the initial and continuing treatment of cancer patients with established VTE; and (5) the impact of anticoagulants on cancer patient survival requires additional study and cannot be recommended at present.
UR - http://www.scopus.com/inward/record.url?scp=36849070772&partnerID=8YFLogxK
U2 - 10.1200/JCO.2007.14.1283
DO - 10.1200/JCO.2007.14.1283
M3 - Article
C2 - 17968019
AN - SCOPUS:36849070772
SN - 0732-183X
VL - 25
SP - 5490
EP - 5505
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 34
ER -