Alzheimer's Disease: MRI Studies

P. M. Thompson; A. W. Toga

doi:10.1016/B978-008045046-9.00547-7

Alzheimer's Disease: MRI Studies

P. M. Thompson, A. W. Toga

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder for those 65. years or older, currently affecting 4.5. million Americans and predicted to rise to 13.2. million by the year 2050 in the US alone. Neuroimaging and brain mappping techniques offer extraordinary power to understand AD, providing spatially detailed information on the extent and trajectory of the disease as it spreads in the living brain. Computational anatomy techniques, applied to databases of MRI scans, reveal the dynamic sequence of brain changes with disease progression, and how these changes relate to cognitive decline and the spread of amyloid plaque and tangle pathology, the molecular causes of AD.

Original language	English
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd.
Pages	269-273
Number of pages	5
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00547-7
State	Published - 2009
Externally published	Yes

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Alzheimer's Disease: MRI Studies

Abstract

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