@article{a893efe5196148bea18d9d90a706131d,
title = "Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies",
abstract = "Worldwide there are over 46 million people living with dementia, and this number is expected to double every 20 years reaching about 131 million by 2050. The cost to the community and government health systems, as well as the stress on families and carers is incalculable. Over three decades of research into this disease have been undertaken by several research groups in Australia, including work by our original research group in Western Australia which was involved in the discovery and sequencing of the amyloid-β peptide (also known as Aβ or A4 peptide) extracted from cerebral amyloid plaques. This review discusses the journey from the discovery of the Aβ peptide in Alzheimer's disease (AD) brain to the establishment of pre-clinical AD using PET amyloid tracers, a method now serving as the gold standard for developing peripheral diagnostic approaches in the blood and the eye. The latter developments for early diagnosis have been largely achieved through the establishment of the Australian Imaging Biomarker and Lifestyle research group that has followed 1,100 Australians for 11 years. AIBL has also been instrumental in providing insight into the role of the major genetic risk factor apolipoprotein E ϵ4, as well as better understanding the role of lifestyle factors particularly diet, physical activity and sleep to cognitive decline and the accumulation of cerebral Aβ.",
keywords = "Alzheimer's disease, Aβ, amyloid, apolipoprotein E, biomarker, dementia, early diagnosis, preclinical",
author = "Martins, {Ralph N.} and Victor Villemagne and Sohrabi, {Hamid R.} and Pratishtha Chatterjee and Shah, {Tejal M.} and Giuseppe Verdile and Paul Fraser and Kevin Taddei and Gupta, {Veer B.} and Rainey-Smith, {Stephanie R.} and Eugene Hone and Steve Pedrini and Lim, {Wei Ling} and Ian Martins and Shaun Frost and Sunil Gupta and Sid O'Bryant and Alan Rembach and David Ames and Kathryn Ellis and Fuller, {Stephanie J.} and Belinda Brown and Gardener, {Samantha L.} and Binosha Fernando and Prashant Bharadwaj and Samantha Burnham and Laws, {Simon M.} and Barron, {Anna M.} and Kathryn Goozee and Wahjoepramono, {Eka J.} and Asih, {Prita R.} and Doecke, {James D.} and Olivier Salvado and Bush, {Ashley I.} and Rowe, {Christopher C.} and Gandy, {Samuel E.} and Masters, {Colin L.}",
note = "Funding Information: aCentre of Excellence for Alzheimer{\textquoteright}s Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia bAustralian Alzheimer{\textquoteright}s Research Foundation, Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, WA, Australia cDepartment of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia dSchool of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth WA, Australia eKaRa Institute of Neurological Diseases, Sydney NSW, Australia fSchool of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University of Technology, Bentley, WA, Australia gSchool of Psychology and Exercise Science, Murdoch University, Perth, WA, Australia hCSIRO Australian e-Health Research Centre/Health and Biosecurity, Perth, WA, Australia iAnglicare, Sydney, NSW, Australia jSchool of Medical Sciences, University of New South Wales, Kensington, NSW, Australia kCSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia lDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA mUniversity of North Texas Health Science Centre, Fort Worth, TX, USA nDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia oFlorey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia pCooperative Research Centre for Mental Health, Carlton, VIC, Australia Publisher Copyright: {\textcopyright} 2018-IOS Press and the authors. All rights reserved.",
year = "2018",
doi = "10.3233/JAD-171145",
language = "English",
volume = "62",
pages = "965--992",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press BV",
number = "3",
}