Alzheimer's Aβ vaccination of rhesus monkeys (Macaca mulatta)

Sam Gandy; Ron B. DeMattos; Cynthia A. Lemere; Frank L. Heppner; Jodi Leverone; Adriano Aguzzi; William B. Ershler; Jinlu Dai; Paul Fraser; Peter St George Hyslop; David M. Holtzman; Lary C. Walker; Evan T. Keller

doi:10.1016/j.mad.2003.12.002

Alzheimer's Aβ vaccination of rhesus monkeys (Macaca mulatta)

Sam Gandy, Ron B. DeMattos, Cynthia A. Lemere, Frank L. Heppner, Jodi Leverone, Adriano Aguzzi, William B. Ershler, Jinlu Dai, Paul Fraser, Peter St George Hyslop, David M. Holtzman, Lary C. Walker, Evan T. Keller

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Recent preliminary data suggest that vaccination with Alzheimer's Aβ might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Aβ-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Aβ ^1-42. Immunized monkeys developed anti-Aβ titers exceeding 1:1000, and their plasma Aβ levels were 5-10-fold higher than the plasma Aβ levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Aβ.

Original language	English
Pages (from-to)	149-151
Number of pages	3
Journal	Mechanisms of Ageing and Development
Volume	125
Issue number	2
DOIs	https://doi.org/10.1016/j.mad.2003.12.002
State	Published - Feb 2004
Externally published	Yes

Keywords

Alzheimer's vaccination
Alzheimers
Immunization
Rhesus monkey

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10.1016/j.mad.2003.12.002

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title = "Alzheimer's Aβ vaccination of rhesus monkeys (Macaca mulatta)",

abstract = "Recent preliminary data suggest that vaccination with Alzheimer's Aβ might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Aβ-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Aβ 1-42. Immunized monkeys developed anti-Aβ titers exceeding 1:1000, and their plasma Aβ levels were 5-10-fold higher than the plasma Aβ levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Aβ.",

keywords = "Alzheimer's vaccination, Alzheimers, Immunization, Rhesus monkey",

author = "Sam Gandy and DeMattos, {Ron B.} and Lemere, {Cynthia A.} and Heppner, {Frank L.} and Jodi Leverone and Adriano Aguzzi and Ershler, {William B.} and Jinlu Dai and Paul Fraser and {St George Hyslop}, Peter and Holtzman, {David M.} and Walker, {Lary C.} and Keller, {Evan T.}",

note = "Funding Information: This work was supported by the National Institute of Neurological Diseases and Stroke. ",

year = "2004",

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doi = "10.1016/j.mad.2003.12.002",

language = "English",

volume = "125",

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T1 - Alzheimer's Aβ vaccination of rhesus monkeys (Macaca mulatta)

AU - Gandy, Sam

AU - DeMattos, Ron B.

AU - Lemere, Cynthia A.

AU - Heppner, Frank L.

AU - Leverone, Jodi

AU - Aguzzi, Adriano

AU - Ershler, William B.

AU - Dai, Jinlu

AU - Fraser, Paul

AU - St George Hyslop, Peter

AU - Holtzman, David M.

AU - Walker, Lary C.

AU - Keller, Evan T.

N1 - Funding Information: This work was supported by the National Institute of Neurological Diseases and Stroke.

PY - 2004/2

Y1 - 2004/2

N2 - Recent preliminary data suggest that vaccination with Alzheimer's Aβ might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Aβ-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Aβ 1-42. Immunized monkeys developed anti-Aβ titers exceeding 1:1000, and their plasma Aβ levels were 5-10-fold higher than the plasma Aβ levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Aβ.

AB - Recent preliminary data suggest that vaccination with Alzheimer's Aβ might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Aβ-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Aβ 1-42. Immunized monkeys developed anti-Aβ titers exceeding 1:1000, and their plasma Aβ levels were 5-10-fold higher than the plasma Aβ levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Aβ.

KW - Alzheimer's vaccination

KW - Alzheimers

KW - Immunization

KW - Rhesus monkey

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Alzheimer's Aβ vaccination of rhesus monkeys (Macaca mulatta)

Abstract

Keywords

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