TY - JOUR
T1 - Alzheimer mutant speeds APP transport
AU - Gandy, Sam
AU - Ehrlich, Michelle E.
N1 - Publisher Copyright:
© 2021 Gandy and Ehrlich.
PY - 2021/6/7
Y1 - 2021/6/7
N2 - APPS198P segregates with rare familial forms of Alzheimer's disease and resides within exon 5, unlike 27 other mutations that reside in exons 16 or 17. In this issue, Zhang et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210313) show that the brains of APPS198P transgenic mice accumulate excess levels of Aβ. In cultured cells, APPS198P undergoes accelerated ER folding, leading to early arrival in late vesicular compartments, thereby enhancing generation of Aβ.
AB - APPS198P segregates with rare familial forms of Alzheimer's disease and resides within exon 5, unlike 27 other mutations that reside in exons 16 or 17. In this issue, Zhang et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210313) show that the brains of APPS198P transgenic mice accumulate excess levels of Aβ. In cultured cells, APPS198P undergoes accelerated ER folding, leading to early arrival in late vesicular compartments, thereby enhancing generation of Aβ.
UR - http://www.scopus.com/inward/record.url?scp=85106546060&partnerID=8YFLogxK
U2 - 10.1084/jem.20210511
DO - 10.1084/jem.20210511
M3 - Comment/debate
C2 - 33988687
AN - SCOPUS:85106546060
SN - 0022-1007
VL - 218
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 6
ER -