Alzheimer disease: Presenilin springs a leak

Sam Gandy; Mark K. Doeven; Bert Poolman

doi:10.1038/nm1006-1121

Alzheimer disease: Presenilin springs a leak

Sam Gandy, Mark K. Doeven, Bert Poolman

Research output: Contribution to journal › Short survey › peer-review

15 Scopus citations

Abstract

Presenilins are thought to contribute to Alzheimer disease through a protein cleavage reaction that produces neurotoxic amyloid-β peptides. A new function for presenilins now comes to light-controlling the leakage of calcium out of the endoplasmic reticulum. Is this a serious challenge to the 'amyloid hypothesis' of Alzheimer disease?

Original language	English
Pages (from-to)	1121-1123
Number of pages	3
Journal	Nature Medicine
Volume	12
Issue number	10
DOIs	https://doi.org/10.1038/nm1006-1121
State	Published - Oct 2006
Externally published	Yes

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title = "Alzheimer disease: Presenilin springs a leak",

abstract = "Presenilins are thought to contribute to Alzheimer disease through a protein cleavage reaction that produces neurotoxic amyloid-β peptides. A new function for presenilins now comes to light-controlling the leakage of calcium out of the endoplasmic reticulum. Is this a serious challenge to the 'amyloid hypothesis' of Alzheimer disease?",

author = "Sam Gandy and Doeven, \{Mark K.\} and Bert Poolman",

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T2 - Presenilin springs a leak

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AU - Doeven, Mark K.

AU - Poolman, Bert

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AB - Presenilins are thought to contribute to Alzheimer disease through a protein cleavage reaction that produces neurotoxic amyloid-β peptides. A new function for presenilins now comes to light-controlling the leakage of calcium out of the endoplasmic reticulum. Is this a serious challenge to the 'amyloid hypothesis' of Alzheimer disease?

UR - https://www.scopus.com/pages/publications/33749512044

U2 - 10.1038/nm1006-1121

DO - 10.1038/nm1006-1121

M3 - Short survey

C2 - 17024202

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VL - 12

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JO - Nature Medicine

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Alzheimer disease: Presenilin springs a leak

Abstract

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