Alternative transcripts of the rat and human dopamine D3 receptor

Lenore A. Snyder, James L. Roberts, Stuart C. Sealfon

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


A cDNA for the rat dopamine D3 receptor containing a 113 bp deletion has been isolated. The segment deleted, encompassing the first extracellular loop and third transmembrane domain, alters the reading frame, introducing 19 amino acids not found in the full length receptor followed by a premature stop codon. This novel mRNA encodes a 109 amino acid protein containing two putative tranmembrane domains. A similar variant cDNA for the human D3 receptor has also been identified.

Original languageEnglish
Pages (from-to)1031-1035
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - 31 Oct 1991
Externally publishedYes


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