Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation

Muhammad Ahmad Maqbool; Léo Pioger; Amal Zine El Aabidine; Nezih Karasu; Anne Marie Molitor; Lan T.M. Dao; Guillaume Charbonnier; Francois van Laethem; Romain Fenouil; Frederic Koch; Georges Lacaud; Ivo Gut; Marta Gut; Sebastian Amigorena; Olivier Joffre; Thomas Sexton; Salvatore Spicuglia; Jean Christophe Andrau

doi:10.1016/j.celrep.2020.108048

Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation

Muhammad Ahmad Maqbool, Léo Pioger, Amal Zine El Aabidine, Nezih Karasu, Anne Marie Molitor, Lan T.M. Dao, Guillaume Charbonnier, Francois van Laethem, Romain Fenouil, Frederic Koch, Georges Lacaud, Ivo Gut, Marta Gut, Sebastian Amigorena, Olivier Joffre, Thomas Sexton, Salvatore Spicuglia, Jean Christophe Andrau

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Development and activation of T lymphocytes are coordinated by lineage-specific transcriptional programs. Here, Maqbool et al. performed a wide epigenomic and transcriptional analysis of mouse T cell differentiation. These data provide new insights into the role of multiple enhancers and PRC2 in controlling alternative promoter choice during differentiation.

Original language	English
Article number	108048
Journal	Cell Reports
Volume	32
Issue number	7
DOIs	https://doi.org/10.1016/j.celrep.2020.108048
State	Published - 18 Aug 2020
Externally published	Yes

Keywords

CapSTARR-seq
T cell enhancerome
enhancer and promoter usage
enhancer redundancy
long-distance enhancer-promoter interactions

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10.1016/j.celrep.2020.108048

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Maqbool, M. A., Pioger, L., El Aabidine, A. Z., Karasu, N., Molitor, A. M., Dao, L. T. M., Charbonnier, G., van Laethem, F., Fenouil, R., Koch, F., Lacaud, G., Gut, I., Gut, M., Amigorena, S., Joffre, O., Sexton, T., Spicuglia, S., & Andrau, J. C. (2020). Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation. Cell Reports, 32(7), Article 108048. https://doi.org/10.1016/j.celrep.2020.108048

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title = "Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation",

abstract = "Development and activation of T lymphocytes are coordinated by lineage-specific transcriptional programs. Here, Maqbool et al. performed a wide epigenomic and transcriptional analysis of mouse T cell differentiation. These data provide new insights into the role of multiple enhancers and PRC2 in controlling alternative promoter choice during differentiation.",

keywords = "CapSTARR-seq, T cell enhancerome, enhancer and promoter usage, enhancer redundancy, long-distance enhancer-promoter interactions",

author = "Maqbool, {Muhammad Ahmad} and L{\'e}o Pioger and {El Aabidine}, {Amal Zine} and Nezih Karasu and Molitor, {Anne Marie} and Dao, {Lan T.M.} and Guillaume Charbonnier and {van Laethem}, Francois and Romain Fenouil and Frederic Koch and Georges Lacaud and Ivo Gut and Marta Gut and Sebastian Amigorena and Olivier Joffre and Thomas Sexton and Salvatore Spicuglia and Andrau, {Jean Christophe}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = aug,

day = "18",

doi = "10.1016/j.celrep.2020.108048",

language = "English",

volume = "32",

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Maqbool, MA, Pioger, L, El Aabidine, AZ, Karasu, N, Molitor, AM, Dao, LTM, Charbonnier, G, van Laethem, F, Fenouil, R, Koch, F, Lacaud, G, Gut, I, Gut, M, Amigorena, S, Joffre, O, Sexton, T, Spicuglia, S & Andrau, JC 2020, 'Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation', Cell Reports, vol. 32, no. 7, 108048. https://doi.org/10.1016/j.celrep.2020.108048

TY - JOUR

T1 - Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation

AU - Maqbool, Muhammad Ahmad

AU - Pioger, Léo

AU - El Aabidine, Amal Zine

AU - Karasu, Nezih

AU - Molitor, Anne Marie

AU - Dao, Lan T.M.

AU - Charbonnier, Guillaume

AU - van Laethem, Francois

AU - Fenouil, Romain

AU - Koch, Frederic

AU - Lacaud, Georges

AU - Gut, Ivo

AU - Gut, Marta

AU - Amigorena, Sebastian

AU - Joffre, Olivier

AU - Sexton, Thomas

AU - Spicuglia, Salvatore

AU - Andrau, Jean Christophe

PY - 2020/8/18

Y1 - 2020/8/18

N2 - Development and activation of T lymphocytes are coordinated by lineage-specific transcriptional programs. Here, Maqbool et al. performed a wide epigenomic and transcriptional analysis of mouse T cell differentiation. These data provide new insights into the role of multiple enhancers and PRC2 in controlling alternative promoter choice during differentiation.

AB - Development and activation of T lymphocytes are coordinated by lineage-specific transcriptional programs. Here, Maqbool et al. performed a wide epigenomic and transcriptional analysis of mouse T cell differentiation. These data provide new insights into the role of multiple enhancers and PRC2 in controlling alternative promoter choice during differentiation.

KW - CapSTARR-seq

KW - T cell enhancerome

KW - enhancer and promoter usage

KW - enhancer redundancy

KW - long-distance enhancer-promoter interactions

UR - http://www.scopus.com/inward/record.url?scp=85089416949&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2020.108048

DO - 10.1016/j.celrep.2020.108048

M3 - Article

C2 - 32814051

AN - SCOPUS:85089416949

SN - 2211-1247

VL - 32

JO - Cell Reports

JF - Cell Reports

IS - 7

M1 - 108048

ER -

Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation

Abstract

Keywords

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