Altered signal transduction in melanoma

Pablo López Bergam; Anindita Bhoumik; Ze'Ev Ronai

doi:10.1007/978-1-59259-994-3_7

Altered signal transduction in melanoma

Pablo López Bergam, Anindita Bhoumik, Ze'Ev Ronai

Icahn School of Medicine at Mount Sinai

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Our understanding of signal transduction pathways involved in the regulation of melanoma development and resistance to treatment has advanced significantly in recent years. Here we focus on the current understanding of major cascades-from the receptors (including HGF, TNFR-associated factors, and Wnt), to kinases (including phosphatidylinositol phosphate 3'-phosphate and mitogen-activated protein kinase), to the affected corresponding transcription factors (including activating transcription factor 2 [ATF2], nuclear factor-κB, β-catenin, and Stat)-that contribute to the course of melanoma development.

Original language	English
Title of host publication	From Melanocytes to Melanoma
Subtitle of host publication	The Progression to Malignancy
Publisher	Humana Press
Pages	119-147
Number of pages	29
ISBN (Print)	1588294595, 9781588294593
DOIs	https://doi.org/10.1007/978-1-59259-994-3_7
State	Published - 2006

Keywords

ATF2
JNK
MET
NF-κB
PI3K
Stat
Stress kinases
TRAF
Wnt
apoptosis
p38

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10.1007/978-1-59259-994-3_7

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abstract = "Our understanding of signal transduction pathways involved in the regulation of melanoma development and resistance to treatment has advanced significantly in recent years. Here we focus on the current understanding of major cascades-from the receptors (including HGF, TNFR-associated factors, and Wnt), to kinases (including phosphatidylinositol phosphate 3'-phosphate and mitogen-activated protein kinase), to the affected corresponding transcription factors (including activating transcription factor 2 [ATF2], nuclear factor-κB, β-catenin, and Stat)-that contribute to the course of melanoma development.",

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TY - CHAP

T1 - Altered signal transduction in melanoma

AU - Bergam, Pablo López

AU - Bhoumik, Anindita

AU - Ronai, Ze'Ev

PY - 2006

Y1 - 2006

N2 - Our understanding of signal transduction pathways involved in the regulation of melanoma development and resistance to treatment has advanced significantly in recent years. Here we focus on the current understanding of major cascades-from the receptors (including HGF, TNFR-associated factors, and Wnt), to kinases (including phosphatidylinositol phosphate 3'-phosphate and mitogen-activated protein kinase), to the affected corresponding transcription factors (including activating transcription factor 2 [ATF2], nuclear factor-κB, β-catenin, and Stat)-that contribute to the course of melanoma development.

AB - Our understanding of signal transduction pathways involved in the regulation of melanoma development and resistance to treatment has advanced significantly in recent years. Here we focus on the current understanding of major cascades-from the receptors (including HGF, TNFR-associated factors, and Wnt), to kinases (including phosphatidylinositol phosphate 3'-phosphate and mitogen-activated protein kinase), to the affected corresponding transcription factors (including activating transcription factor 2 [ATF2], nuclear factor-κB, β-catenin, and Stat)-that contribute to the course of melanoma development.

KW - ATF2

KW - JNK

KW - MET

KW - NF-κB

KW - PI3K

KW - Stat

KW - Stress kinases

KW - TRAF

KW - Wnt

KW - apoptosis

KW - p38

UR - https://www.scopus.com/pages/publications/84891439444

U2 - 10.1007/978-1-59259-994-3_7

DO - 10.1007/978-1-59259-994-3_7

M3 - Chapter

AN - SCOPUS:84891439444

SN - 1588294595

SN - 9781588294593

SP - 119

EP - 147

BT - From Melanocytes to Melanoma

PB - Humana Press

ER -

Altered signal transduction in melanoma

Abstract

Keywords

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