Altered serotonin 2C receptor RNA splicing in suicide: Association with editing

Stella Dracheva, Benjamin Chin, Vahram Haroutunian

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

In an earlier study, we showed increases in serotonin 2C receptor (5-HT2CR) pre-mRNA editing in prefrontal cortex that were specific to suicide victims irrespective of associated psychiatric diagnoses. Here we demonstrate that the ratio between the two 5-HT2CR splice variants is increased in people who committed suicide, but does not vary among the diagnostic groups. This provides further evidence for suicide-specific neurobiology and suggests that, as it was previously shown in vitro, 5-HT2CR editing modulates its splicing in human brain. The association analysis indicates, however, that the efficiency of 5-HT2CR editing is an imperfect predictor of the splicing outcome, and that splice site selection is only partially controlled by the level of editing in vivo.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalNeuroReport
Volume19
Issue number3
DOIs
StatePublished - Feb 2008

Keywords

  • Serotonin 2C receptor
  • Splice variant
  • Suicide
  • mRNA editing

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